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Literature summary for 4.4.1.20 extracted from
- Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone (2004), J. Enzyme Inhib. Med. Chem., 19, 431-436.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | leukotrienes are an important therapeutic target in asthma and inflammatory diseases | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene C4 | Homo sapiens | - |
leukotriene A4 + glutathione | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16873 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 | - |
r | |
| leukotriene C4 | - |
Homo sapiens | leukotriene A4 + glutathione | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| leukotriene C4 synthase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione | IC50 value | Homo sapiens | |
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