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Literature summary for 4.4.1.20 extracted from

  • Lam, B.K.; Penrose, J.F.; Rokach, J.; Xu, K.; Baldasaro, M.H.; Austen, K.F.
    Molecular cloning, expression and characterization of mouse leukotriene C4 synthase (1996), Eur. J. Biochem., 238, 606-612.
    View publication on PubMed
Search for more literature for 4.4.1.20

Cloned(Commentary)

Cloned (Comment) Organism
COS-7 cells transfected with either human or cloned mouse leukotriene C4 synthase cDNA by DEAE-dextran transfection Mus musculus
COS-7 cells transfected with either human or cloned mouse leukotriene C4 synthase cDNA by DEAE-dextran transfection Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
MK-886 IC50: 0.0027 mM Homo sapiens
MK-886 IC50: 0.0031 mM Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
heart
-
 Mus musculus
-
heart
-
 Homo sapiens
-
kidney
-
 Mus musculus
-
kidney
-
 Homo sapiens
-
lung
-
 Mus musculus
-
lung
-
 Homo sapiens
-
mast cell bone-marrow-derived Mus musculus
-
pancreas
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
skeletal muscle
-
 Mus musculus
-
skeletal muscle
-
 Homo sapiens
-
spleen slight Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + glutathione
-
 Mus musculus leukotriene C4 + H2O
-
 ?
leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4 + H2O
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0027
-
 IC50: 0.0027 mM Homo sapiens MK-886
0.0031
-
 IC50: 0.0031 mM Mus musculus MK-886