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Literature summary for 4.4.1.20 extracted from
- Conversion of leukotrienes A4 to C4 in cell-free systems (1986), Biochem. Biophys. Res. Commun., 134, 85-92.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | the enzyme is chiefly membrane-bound, although the cytosol contains some activity | Cavia porcellus | 5829 | - |
| cytosol | the enzyme is chiefly membrane-bound, although the cytosol contains some activity | Homo sapiens | 5829 | - |
| cytosol | the enzyme is chiefly membrane-bound, although the cytosol contains some activity | Rattus norvegicus | 5829 | - |
| membrane | the enzyme is chiefly membrane-bound, although the cytosol contains some activity | Cavia porcellus | 16020 | - |
| membrane | the enzyme is chiefly membrane-bound, although the cytosol contains some activity | Homo sapiens | 16020 | - |
| membrane | the enzyme is chiefly membrane-bound, although the cytosol contains some activity | Rattus norvegicus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Cavia porcellus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Cavia porcellus | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Rattus norvegicus | - |
| nasal polyp | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + glutathione | - |
Cavia porcellus | leukotriene C4 + H2O | - |
? |  |
| leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 + H2O | - |
? | |
| leukotriene A4 + glutathione | - |
Rattus norvegicus | leukotriene C4 + H2O | - |
? | |
| leukotriene A4 methyl ester + glutathione | - |
Cavia porcellus | leukotriene C4 methyl ester + H2O | - |
? | |
| leukotriene A4 methyl ester + glutathione | - |
Homo sapiens | leukotriene C4 methyl ester + H2O | - |
? | |
| leukotriene A4 methyl ester + glutathione | - |
Rattus norvegicus | leukotriene C4 methyl ester + H2O | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
lung enzyme, reaction with leukotriene A4 methyl ester | Rattus norvegicus |
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