Protein Variants | Comment | Organism |
---|---|---|
A52S | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
C56S | mutant enzyme without altered function | Homo sapiens |
C56S/C82 | mutant enzyme without altered function | Homo sapiens |
C82V | mutant enzyme without altered function | Homo sapiens |
N55A | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
R51H | fully active mutant enzyme | Homo sapiens |
R51I | mutant enzyme without activity | Homo sapiens |
R51K | fully active mutant enzyme | Homo sapiens |
R51T | mutant enzyme without activity | Homo sapiens |
V49F | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
Y59F | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
Y93F | activity of the mutant enzyme is less than 1% of the wild-type enzyme, shift in pH optimum of the residual activity to that of spontaneous conjugation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NEM | - |
Cavia porcellus | |
NEM | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mg2+ | enhances activity | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + glutathione | - |
Cavia porcellus | leukotriene C4 + H2O | - |
? | |
leukotriene A4 + glutathione | - |
Mus musculus | leukotriene C4 + H2O | - |
? | |
leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 + H2O | - |
? | |
leukotriene A4 + glutathione | - |
Rattus norvegicus | leukotriene C4 + H2O | - |
? |