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Literature summary for 4.4.1.2 extracted from

  • Thong, K.W.; Coombs, G.H.
    Homocysteine desulphurase activity in trichomonads (1985), IRCS Med. Sci. Libr. Compend., 13, 493-494.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
DL-Penicillamine
-
Trichomonas vaginalis
DL-propargylglycine
-
Trichomonas vaginalis
hydroxylamine
-
Trichomonas vaginalis
L-Cycloserine
-
Trichomonas vaginalis

Organism

Organism UniProt Comment Textmining
no activity in Crithidia fasciculata
-
-
-
no activity in Entamoeba histolytica
-
-
-
no activity in Escherichia coli
-
-
-
no activity in Herpetomonas muscarum
-
-
-
no activity in Leishmania mexicana mexicana
-
amastigotes and promastigotes
-
no activity in Leishmania tarentolae
-
-
-
no activity in mouse
-
liver
-
no activity in Tetrahymena pyriformis
-
-
-
no activity in Trichomonas foetus
-
-
-
Trichomonas batrachorum
-
weak
-
Trichomonas vaginalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-homocysteine + H2O
-
Trichomonas vaginalis H2S + NH3 + 2-oxobutanoate
-
?
L-homocysteine + H2O
-
Trichomonas batrachorum H2S + NH3 + 2-oxobutanoate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Trichomonas vaginalis