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Literature summary for 4.4.1.17 extracted from

  • Mendez, D.L.; Babbitt, S.E.; King, J.D.; DAlessandro, J.; Watson, M.B.; Blankenship, R.E.; Mirica, L.M.; Kranz, R.G.
    Engineered holocytochrome c synthases that biosynthesize new cytochromes c (2017), Proc. Natl. Acad. Sci. USA, 114, 2235-2240 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
synthesis mutants E159A and W118A display enhanced release of cytochrome c from the active site. The mutant allows for synthesis of cytochrome c variants such as cyt c H19M (bis-Met), cyt c M81H (bis-His), cyt c M81A (His/OH), cyt c C15S, which exhibit proper folding Homo sapiens

Protein Variants

Protein Variants Comment Organism
E159A mutant displays enhanced release of cytochrome c from the active site. The mutant allows for synthesis of cytochrome c variants such as cyt c H19M (bis-Met), cyt c M81H (bis-His), cyt c M81A (His/OH?), cyt c C15S which exhibit proper folding Homo sapiens
W118A mutant displays enhanced release of cytochrome c from the active site. The mutant allows for synthesis of cytochrome c variants such as cyt c H19M (bis-Met), cyt c M81H (bis-His), cyt c M81A (His/OH), cyt c C15S which exhibit proper folding Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P53701
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