Literature summary for 4.4.1.17 extracted from

Babbitt, S.E.; Hsu, J.; Kranz, R.G.
Molecular basis behind inability of mitochondrial holocytochrome c synthase to mature bacterial cytochromes Defining a critical role for cytochrome c alpha helix-1 (2016), J. Biol. Chem., 291, 17523-17534 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P53701	-	-

General Information

General Information	Comment	Organism
physiological function	human cyts c with deletion of a single residues in helix-1, DELTA M13 cyt c, is poorly matured by human HCCS. Although an HCCS-wild-type cytochrome c complex contains two covalent links, HCCS DELTA M13 cytochrome c contains only one thioether attachment. This attachment is to the second thiol of residues C15SQC18H. The serine residue (of CSQCH) would be anchored where the first cysteine should be in DELTA M13 cytochrome c. An engineered cytochrome c with a CQCH motif in the DELTA M13 background is matured at 2-3fold higher levels	Homo sapiens

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Release 2023.1 (January 2023)