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Literature summary for 4.4.1.16 extracted from

  • Daher, R.; Van Lente, F.
    Characterization of selenocysteine lyase in human tissues and its relationship to tissue selenium concentrations (1992), J. Trace Elem. Electrolytes Health Dis., 6, 189-194.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-cysteine noncompetitive Homo sapiens
L-cysteine noncompetitive Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
L-selenocysteine
-
Homo sapiens
0.5
-
L-selenocysteine
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-selenocysteine + reduced acceptor Homo sapiens
-
selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor Sus scrofa
-
selenide + L-alanine + acceptor
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-
adrenal gland
-
Sus scrofa
-
heart
-
Homo sapiens
-
heart
-
Sus scrofa
-
kidney
-
Homo sapiens
-
kidney
-
Sus scrofa
-
liver
-
Homo sapiens
-
liver
-
Sus scrofa
-
muscle
-
Homo sapiens
-
muscle
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-selenocysteine + reduced acceptor
-
Homo sapiens selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Sus scrofa selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Homo sapiens selenide + L-alanine + acceptor H2Se detected as product ?
L-selenocysteine + reduced acceptor
-
Sus scrofa selenide + L-alanine + acceptor H2Se detected as product ?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate required Homo sapiens
pyridoxal 5'-phosphate required Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.85
-
L-cysteine
-
Homo sapiens
5.85
-
L-cysteine
-
Sus scrofa