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Literature summary for 4.4.1.13 extracted from

  • Ejim, L.J.; D'Costa, V.M.; Elowe, N.H.; Loredo-Osti, J.C.; Malo, D.; Wright, G.D.
    Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium (2004), Infect. Immun., 72, 3310-3314.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.4.1.13

Application

Application Comment Organism
medicine the enzyme is important for bacterial virulence and is therefor a potential target for antibacterial drug development Salmonella enterica

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme is not inhibited by pyridamine antimicrobial agents (pyrimethanil, cyprodinil or mepanipyrim) Salmonella enterica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.38
-
 cystathionine
-
 Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Salmonella enterica the enzyme catalyzes the penultimate step in methionine biosynthesis. The enzyme is important for bacterial virulence ?
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
 serovar typhimurium
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cystathionine + H2O
-
 Salmonella enterica L-homocysteine + NH3 + pyruvate
-
 ?
additional information the enzyme catalyzes the penultimate step in methionine biosynthesis. The enzyme is important for bacterial virulence Salmonella enterica ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.5
-
 cystathionine
-
 Salmonella enterica