Application | Comment | Organism |
---|---|---|
medicine | possible beneficial or useful consequences of cysteine S-conjugate beta-lyase activity include targeting of prodrugs. They can unmask suitably designed prodrugs in target tumors/tissues. Other favorable beta-lyase reactions are associated with activation of S-cysteine conjugates derived from allium foods into reactive persulfide or sulfane sulfur progenitors. Allium-derived S-allylcysteinyl constituents are effective inhibitors of the cancer process. Thus the study of the biochemistry of allium-derived cysteine S-conjugates may lead to new avenues for cancer treatment | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
RS-CH2-CH(NH3+)COO- + H2O | Rattus norvegicus | - |
RSH + NH3 + pyruvate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
approximately between 0.6 and 6.4 with S-(1,2-dichlorovinyl)-L-cysteine or S-(1,1,2,2-tetrafluoroethyl)-L-cysteine as substrate | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
RS-CH2-CH(NH3+)COO- + H2O | - |
Rattus norvegicus | RSH + NH3 + pyruvate | - |
ir | |
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O | - |
Rattus norvegicus | NH3 + pyruvate + 1,1,2,2-tetrafluoroethanethiol | - |
ir | |
S-(1,2-dichlorovinyl)-L-cysteine + H2O | - |
Rattus norvegicus | NH3 + pyruvate + 1,2-dichloroethylenethiol | - |
ir | |
S-allyl-L-cysteine + H2O | - |
Rattus norvegicus | NH3 + pyruvate + prop-2-ene-1-thiol | - |
ir | |
S-allylmercapto-L-cysteine + H2O | - |
Rattus norvegicus | NH3 + pyruvate + allyl hydrodisulfide | - |
ir | |
S-methylmercapto-L-cysteine + H2O | - |
Rattus norvegicus | NH3 + pyruvate + methanethiol | - |
ir | |
S-penta-1,3-dienylmercapto-L-cysteine + H2O | - |
Rattus norvegicus | NH3 + pyruvate + penta-1,3-dien-1-yl hydrodisulfide | - |
ir | |
S-propylmercapto-L-cysteine + H2O | - |
Rattus norvegicus | NH3 + pyruvate + propyl hydrodisulfide | - |
ir | |
Te-phenyl-L-tellurocysteine + H2O | - |
Rattus norvegicus | NH3 + pyruvate + phenyltelluride | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
cysteine S-conjugate beta-lyase | - |
Rattus norvegicus |
glutamine transaminase K | - |
Rattus norvegicus |
GTK | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus |