Literature summary for 4.4.1.11 extracted from

McKie, A.E.; Edlind, T.; Walker, J.; Mottram, J.C.; Coombs, G.H.
The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5 -phosphate-dependent enzymes (1998), J. Biol. Chem., 273, 5549-5556.

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Protein Variants

Protein Variants	Comment	Organism
C113G	MGL1, reduced activity towards methionine and homocysteine	Trichomonas vaginalis
C116G	MGL2, reduced activity towards methionine and homocysteine	Trichomonas vaginalis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.6	-	cysteine	recombinant, MGL2 C116G	Trichomonas vaginalis
4.3	-	L-methionine	-	Trichomonas vaginalis
6.2	-	L-ethionine	recombinant MGL2, C116G	Trichomonas vaginalis
8.5	-	cysteine	recombinant MGL1	Trichomonas vaginalis
9.7	-	cysteine	recombinant MGL1, C113G	Trichomonas vaginalis
12.2	-	L-ethionine	recombinant MGL1	Trichomonas vaginalis
15.2	-	L-ethionine	recombinant MGL1, C113G	Trichomonas vaginalis
22.3	-	cysteine	recombinant MGL2	Trichomonas vaginalis
37.2	-	L-ethionine	recombinant MGL2	Trichomonas vaginalis

Organism

Organism	UniProt	Comment	Textmining
Trichomonas vaginalis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-cysteine + H2O	-	Trichomonas vaginalis	?	-	?
L-ethionine + H2O	-	Trichomonas vaginalis	?	-	?

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Trichomonas vaginalis

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Release 2023.1 (January 2023)