Cloned (Comment) | Organism |
---|---|
use of Escherichia coli codon-optimized gene | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
structures of mutant E59N/R119L/E339V with distinct reaction intermediates, including internal aldimine, substrate-bound, gem-diamine, and external aldimine forms. A locally unfolded active site correlates with inhibition of activity as a function of ionic strength | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E59N/R119L/E339V | mutant engineered as an L-Met-degrading enzyme based on the human cystathionine-gamma-lyase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P32929 | - |
- |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | a salt bridge between the phosphate of cofactor pyridoxal 5'-phosphate and residue R62 plays an important role in catalyzing beta- and gamma-eliminations | Homo sapiens |