Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.4.1.1 extracted from

  • Leucker, T.M.; Nomura, Y.; Kim, J.H.; Bhatta, A.; Wang, V.; Wecker, A.; Jandu, S.; Santhanam, L.; Berkowitz, D.; Romer, L.; Pandey, D.
    Cystathionine gamma-lyase protects vascular endothelium a role for inhibition of histone deacetylase 6 (2017), Am. J. Physiol. Heart Circ. Physiol., 312, H711-H720 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
transfection into HEK-293 cells Homo sapiens
transfection into HEK-293 cells Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P32929
-
-
Mus musculus Q8VCN5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Mus musculus
-
aortic endothelial cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
CSEgamma
-
Homo sapiens
CSEgamma
-
Mus musculus
CTH
-
Homo sapiens
CTH
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus aortas from atherogenic apolipoprotein E knockout mice fed a high-fat diet show reduced CSEgamma mRNA expression and protein abundance down
Homo sapiens human aortic endothelial cells exposed to oxidized LDL show reduced CSEgamma mRNA expression and protein abundance down
Homo sapiens CSEgamma expression is upregulated by pan-histone deacetylase inhibitors and by class II-specific HDAC inhibitors, but not by other class-specific inhibitors. The histone deacetylase 6 selective inhibitor tubacin and histone deacetylase 6-specific siRNA increase CSEgamma expression and block oxidized LDL-mediated reductions in endothelial CSEgamma expression and CSEgamma promoter activity up

General Information

General Information Comment Organism
physiological function aortas from atherogenic apolipoprotein E knockout mice fed a high-fat diet show reduced CSEgamma mRNA expression and protein abundance Mus musculus
physiological function CSEgamma expression is upregulated by pan-histone deacetylase inhibitors and by class II-specific HDAC inhibitors, but not by other class-specific inhibitors. The histone deacetylase 6 selective inhibitor tubacin and histone deacetylase 6-specific siRNA increase CSEgamma expression and block oxidized LDL-mediated reductions in endothelial CSEgamma expression and CSEgamma promoter activity Homo sapiens