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Literature summary for 4.4.1.1 extracted from

  • Giordana, L.; Mantilla, B.S.; Santana, M.; Silber, A.M.; Nowicki, C.
    Cystathionine gamma-lyase, an enzyme related to the reverse transsulfuration pathway, is functional in Leishmania spp. (2014), J. Eukaryot. Microbiol., 61, 204-213.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene LmjF35.3230 or Lmj_CGL, functional complementation of a CGL null mutant strain DELTA CYS3 of Saccharomyces cerevisiae Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
DL-propargylglycine an irreversible enzyme inhibitor, molecular mechanism of DL-propargylglycine action in vivo Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Leishmania mexicana 5829
-
cytosol
-
Leishmania major 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cystathionine + H2O Leishmania mexicana
-
L-cysteine + 2-oxobutanoate + NH3
-
r
L-cystathionine + H2O Leishmania major
-
L-cysteine + 2-oxobutanoate + NH3
-
r

Organism

Organism UniProt Comment Textmining
Leishmania major E9AFE7 gene LmjF35.3230 or Lmj_CGL
-
Leishmania mexicana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
Leishmania mexicana
-
promastigote
-
Leishmania major
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.49
-
cell-free extract of promastigotes, pH 8.0, 37°C Leishmania mexicana
0.49
-
cell-free extract of promastigotes, pH 8.0, 37°C Leishmania major

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cystathionine + H2O
-
Leishmania mexicana L-cysteine + 2-oxobutanoate + NH3
-
r
L-cystathionine + H2O
-
Leishmania major L-cysteine + 2-oxobutanoate + NH3
-
r

Synonyms

Synonyms Comment Organism
cgl
-
Leishmania mexicana
cgl
-
Leishmania major

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Leishmania mexicana
37
-
assay at Leishmania major

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Leishmania mexicana
8
-
assay at Leishmania major

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Leishmania mexicana
pyridoxal 5'-phosphate
-
Leishmania major

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.065
-
pH 7.4, 37°C Leishmania major DL-propargylglycine

General Information

General Information Comment Organism
additional information the Leishmania major enzyme is able to rescue the wild-type phenotype of a Saccharomyces cerevisiae enzyme-null mutant Leishmania major