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Literature summary for 4.4.1.1 extracted from

  • Asimakopoulou, A.; Panopoulos, P.; Chasapis, C.T.; Coletta, C.; Zhou, Z.; Cirino, G.; Giannis, A.; Szabo, C.; Spyroulias, G.A.; Papapetropoulos, A.
    Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) (2013), Br. J. Pharmacol., 169, 922-932.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) Codon Plus using expression vector pGEX-4T3/GST-CSE Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
aminooxyacetic acid
-
Escherichia coli
Beta-cyanoalanine
-
Escherichia coli
hydroxylamine
-
Escherichia coli
isoniazid
-
Escherichia coli
L-aminoethoxyvinylglycine
-
Escherichia coli
additional information no or poor inhibition by methylselenocysteine, D-cycloserine, pargyline, and parsalmide Escherichia coli
propargylglycine
-
Escherichia coli
trifluoroalanine
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cystathionine + H2O Escherichia coli
-
L-cysteine + 2-oxobutanoate + NH3
-
?
L-cysteine + H2O Escherichia coli
-
H2S + pyruvate + NH3
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) Codon Plus by metal affinity chromatography Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cystathionine + H2O
-
Escherichia coli L-cysteine + 2-oxobutanoate + NH3
-
?
L-cysteine + H2O
-
Escherichia coli H2S + pyruvate + NH3
-
?

Synonyms

Synonyms Comment Organism
CSE
-
Escherichia coli
cystathionine gamma lyase
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics, overview Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
pH 8.2, 37°C Escherichia coli L-aminoethoxyvinylglycine
0.0011
-
pH 8.2, 37°C Escherichia coli aminooxyacetic acid
0.0048
-
pH 8.2, 37°C Escherichia coli hydroxylamine
0.014
-
pH 8.2, 37°C Escherichia coli Beta-cyanoalanine
0.04
-
pH 8.2, 37°C Escherichia coli propargylglycine
0.289
-
pH 8.2, 37°C Escherichia coli trifluoroalanine

General Information

General Information Comment Organism
metabolism the enzyme is involved in H2S biosynthesis Escherichia coli