Literature summary for 4.4.1.1 extracted from

You, X.J.; Xu, C.; Lu, J.Q.; Zhu, X.Y.; Gao, L.; Cui, X.R.; Li, Y.; Gu, H.; Ni, X.
Expression of cystathionine beta-synthase and cystathionine gamma-lyase in human pregnant myometrium and their roles in the control of uterine contractility (2011), PLoS ONE, 6, e23788.

Search for more literature for 4.4.1.1

Application

Application	Comment	Organism
medicine	cumulative administration of L-cysteine causes a dose-dependent decrease in the amplitude of spontaneous contractions in nonlabouring and labouring myometrium strips. L-cysteine at high concentration increases the frequency of spontaneous contractions and induces tonic contraction. These effects of L-cysteine are blocked by inhibitors of cystathionen beta-synthase and cystathionine gamma-lyase. Pretreatment of myometrium strips with glibenclamide, an inhibitor of ATP-sensitive potassium channels, abolishes the inhibitory effect of L-cysteine on spontaneous contraction amplitude. The effects of L-cysteine on the amplitude of spontaneous contractions and baseline muscle tone are less potent in labouring tissues than that in nonlabouring strips	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
45000	-	x * 45000, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
myometrium	pregnant myometrium, primarily localized to smooth muscle cells of pregnant myometrium	Homo sapiens	-
smooth muscle	primarily localized to smooth muscle cells of pregnant myometrium	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 45000, SDS-PAGE	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	human myometrium smooth muscle cells express cystathionine beta-synthase and cystathionine gamma-lyase. Endogenous H2S generated by cystathionine beta-synthase and cystathionine gamma-lyase locally modulates the contractility of pregnant myometrium	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)