Literature summary for 4.4.1.1 extracted from

Mani, S.; Yang, G.; Wang, R.
A critical life-supporting role for cystathionine ?-lyase in the absence of dietary cysteine supply (2011), Free Radic. Biol. Med., 50, 1280-1287.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

General Information

General Information	Comment	Organism
physiological function	Mice with a targeted deletion of the CSE gene fed a cysteine-limited diet exhibit growth retardation, decreased levels of cysteine, glutathione, and H2S, and increased plasma homocysteine level. Histological examinations of liver do not reveal any abnormality and plasma levels of aspartate aminotransferase, alanine aminotransferase, and albumin are normal in these animals. No CSE-KO mice survive after 12 weeks of feeding with the cysteine-limited diet. Supplementation of H2S to the CSE-KO mice fails to reverse the aforementioned abnormalities. Supplementation of cysteine in the drinking water of the CSE-KO mice significantly increases plasma cysteine and glutathione levels. This eventually leads to an increase in body weight and rescues the animals from death	Mus musculus

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Release 2023.1 (January 2023)