Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.4.1.1 extracted from

  • Yang, G.; Wu, L.; Jiang, B.; Yang, W.; Qi, J.; Cao, K.; Meng, Q.; Mustafa, A.K.; Mu, W.; Zhang, S.; Snyder, S.H.; Wang, R.
    H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase (2008), Science, 322, 587-590.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
calcium-calmodulin catalytic activity of pure CSE is increased more than 2fold by calcium and calmodulin, but not by either substance alone Mus musculus

Application

Application Comment Organism
additional information H2S is a physiologic vasodilator and regulator of blood pressure Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information CSE-/- mice and CSE-/+ mice, mice genetically deficient in this enzyme display marked hypertension, comparable to that of eNOS-/- mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
DL-propargylglycine elevates blood pressure Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Mus musculus
-
blood vessel predominantly localized to the endothelial layer of blood vessels Mus musculus
-
endothelial cell
-
Mus musculus
-
heart
-
Mus musculus
-
serum
-
Mus musculus
-
vascular system
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
CSE
-
Mus musculus
cystathionine gamma-lyase
-
Mus musculus