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Literature summary for 4.4.1.1 extracted from

  • Lo, R.; Turner, M.S.; Barry, D.G.; Sreekumar, R.; Walsh, T.P.; Giffard, P.M.
    Cystathionine {gamma}-lyase is a component of cystine-mediated oxidative defense in Lactobacillus reuteri BR11 (2009), J. Bacteriol., 191, 1827-1837.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Limosilactobacillus reuteri

Protein Variants

Protein Variants Comment Organism
additional information PNG902 and PNG903 strains (cgl, cyuC and mlp mutants), constructing a cgl mutant (PNG901) and comparing it to a similarly constructed cyuC mutant (PNG902). The growth defects in aerated cultures of both mutants are alleviated by supplementation with cysteine (and cystine in the cgl mutant) but not methionine, with the cyuC mutant showing a much higher requirement Limosilactobacillus reuteri

Organism

Organism UniProt Comment Textmining
Limosilactobacillus reuteri
-
BR11
-
Limosilactobacillus reuteri BR11
-
BR11
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cystine + H2O
-
Limosilactobacillus reuteri NH3 + pyruvate + L-thiocysteine
-
?
L-cystine + H2O
-
Limosilactobacillus reuteri BR11 NH3 + pyruvate + L-thiocysteine
-
?

Synonyms

Synonyms Comment Organism
cgl
-
Limosilactobacillus reuteri
cystathionine gamma-lyase
-
Limosilactobacillus reuteri

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Limosilactobacillus reuteri