Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cys | - |
Rattus norvegicus | |
Cys | the regulatory site of the enzyme is specific for L-Cys | Streptomyces phaeochromogenes |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Streptomyces phaeochromogenes | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3 | the active site consists of two subsites. One recognizes the L-form of amino acids and the other shows affinity for thiol compounds with a carbonyl group | Streptomyces phaeochromogenes |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Cys + D-homoserine | - |
Streptomyces phaeochromogenes | D-cystathionine | - |
? | |
D-Cys + L-homoserine | - |
Rattus norvegicus | D-allocystathionine | - |
? | |
D-Cys + L-homoserine | at 318% of the activity with L-homocysteine and L-cysteine | Streptomyces phaeochromogenes | D-allocystathionine | - |
? | |
D-Cys + L-homoserine | gamma-replacement | Streptomyces phaeochromogenes | D-allocystathionine | - |
? | |
L-Cys + D-homoserine | - |
Streptomyces phaeochromogenes | L-allocystathionine | - |
? | |
L-homoserine + 2-mercaptoethanol | 8% of the activity with L-homocysteine and L-Cys | Streptomyces phaeochromogenes | S-hydroxyethyl-L-homocysteine | - |
? | |
L-homoserine + 2-mercaptopropionate | - |
Rattus norvegicus | S-methylcarboxymethyl-L-homocysteine | - |
? | |
L-homoserine + 2-mercaptopropionate | gamma-replacement reaction | Streptomyces phaeochromogenes | S-methylcarboxymethyl-L-homocysteine | - |
? | |
L-homoserine + 2-mercaptopropionate | 73% of the activity with L-homocysteine and L-Cys | Streptomyces phaeochromogenes | S-methylcarboxymethyl-L-homocysteine | - |
? | |
L-homoserine + 3-mercaptopropionate | - |
Rattus norvegicus | S-carboxyethyl-L-homocysteine | - |
? | |
L-homoserine + 3-mercaptopropionate | 187% of the activity with L-homocysteine and L-Cys | Streptomyces phaeochromogenes | S-carboxyethyl-L-homocysteine | - |
? | |
L-homoserine + 3-mercaptopropionate | gamma-replacement reaction | Streptomyces phaeochromogenes | S-carboxyethyl-L-homocysteine | - |
? | |
L-homoserine + 4-mercaptobutanoate | 14% of the activity with L-homocysteine and L-Cys | Streptomyces phaeochromogenes | S-carboxy-n-propyl-L-homocysteine | - |
? | |
L-homoserine + D-homocysteine | - |
Rattus norvegicus | meso-homolanthionine | - |
? | |
L-homoserine + D-homocysteine | gamma-replacement reaction, 368% of the activity with L-homocysteine and L-Cys | Streptomyces phaeochromogenes | meso-homolanthionine | - |
? | |
L-homoserine + L-Cys | - |
Streptomyces phaeochromogenes | L-cystathionine | - |
? | |
L-homoserine + L-homocysteine | - |
Rattus norvegicus | L-homolanthionine | - |
? | |
L-homoserine + L-homocysteine | gamma-replacement reaction, 314% of the activity with L-homocysteine and L-Cys | Streptomyces phaeochromogenes | L-homolanthionine | - |
? | |
L-homoserine + thioglycerol | 5% of the activity with L-homocysteine and L-Cys | Streptomyces phaeochromogenes | S-(2,3-dihydroxypropyl)-L-homocysteine | - |
? | |
L-homoserine + thioglycolate | - |
Rattus norvegicus | S-carboxymethyl-L-homocysteine | - |
? | |
L-homoserine + thioglycolate | gamma-replacement reaction, 69% of the activity with L-homocysteine and L-Cys | Streptomyces phaeochromogenes | S-carboxymethyl-L-homocysteine | - |
? | |
additional information | the Streptomyces enzyme has a lower substrate specificity than the rat-liver one | Rattus norvegicus | ? | - |
? | |
additional information | the Streptomyces enzyme has a lower substrate specificity than the rat-liver one | Streptomyces phaeochromogenes | ? | - |
? |