Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.4.1.1 extracted from

  • Kanzaki, H.; Nagasawa, T.; Yamada, H.
    Insight into the active site of Streptomyces cystathionine gamma-lyase based on the results of studies on its substrate specificity (1987), Biochim. Biophys. Acta, 913, 45-50.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cys
-
Rattus norvegicus
Cys the regulatory site of the enzyme is specific for L-Cys Streptomyces phaeochromogenes

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Streptomyces phaeochromogenes
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3 the active site consists of two subsites. One recognizes the L-form of amino acids and the other shows affinity for thiol compounds with a carbonyl group Streptomyces phaeochromogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Cys + D-homoserine
-
Streptomyces phaeochromogenes D-cystathionine
-
?
D-Cys + L-homoserine
-
Rattus norvegicus D-allocystathionine
-
?
D-Cys + L-homoserine at 318% of the activity with L-homocysteine and L-cysteine Streptomyces phaeochromogenes D-allocystathionine
-
?
D-Cys + L-homoserine gamma-replacement Streptomyces phaeochromogenes D-allocystathionine
-
?
L-Cys + D-homoserine
-
Streptomyces phaeochromogenes L-allocystathionine
-
?
L-homoserine + 2-mercaptoethanol 8% of the activity with L-homocysteine and L-Cys Streptomyces phaeochromogenes S-hydroxyethyl-L-homocysteine
-
?
L-homoserine + 2-mercaptopropionate
-
Rattus norvegicus S-methylcarboxymethyl-L-homocysteine
-
?
L-homoserine + 2-mercaptopropionate gamma-replacement reaction Streptomyces phaeochromogenes S-methylcarboxymethyl-L-homocysteine
-
?
L-homoserine + 2-mercaptopropionate 73% of the activity with L-homocysteine and L-Cys Streptomyces phaeochromogenes S-methylcarboxymethyl-L-homocysteine
-
?
L-homoserine + 3-mercaptopropionate
-
Rattus norvegicus S-carboxyethyl-L-homocysteine
-
?
L-homoserine + 3-mercaptopropionate 187% of the activity with L-homocysteine and L-Cys Streptomyces phaeochromogenes S-carboxyethyl-L-homocysteine
-
?
L-homoserine + 3-mercaptopropionate gamma-replacement reaction Streptomyces phaeochromogenes S-carboxyethyl-L-homocysteine
-
?
L-homoserine + 4-mercaptobutanoate 14% of the activity with L-homocysteine and L-Cys Streptomyces phaeochromogenes S-carboxy-n-propyl-L-homocysteine
-
?
L-homoserine + D-homocysteine
-
Rattus norvegicus meso-homolanthionine
-
?
L-homoserine + D-homocysteine gamma-replacement reaction, 368% of the activity with L-homocysteine and L-Cys Streptomyces phaeochromogenes meso-homolanthionine
-
?
L-homoserine + L-Cys
-
Streptomyces phaeochromogenes L-cystathionine
-
?
L-homoserine + L-homocysteine
-
Rattus norvegicus L-homolanthionine
-
?
L-homoserine + L-homocysteine gamma-replacement reaction, 314% of the activity with L-homocysteine and L-Cys Streptomyces phaeochromogenes L-homolanthionine
-
?
L-homoserine + thioglycerol 5% of the activity with L-homocysteine and L-Cys Streptomyces phaeochromogenes S-(2,3-dihydroxypropyl)-L-homocysteine
-
?
L-homoserine + thioglycolate
-
Rattus norvegicus S-carboxymethyl-L-homocysteine
-
?
L-homoserine + thioglycolate gamma-replacement reaction, 69% of the activity with L-homocysteine and L-Cys Streptomyces phaeochromogenes S-carboxymethyl-L-homocysteine
-
?
additional information the Streptomyces enzyme has a lower substrate specificity than the rat-liver one Rattus norvegicus ?
-
?
additional information the Streptomyces enzyme has a lower substrate specificity than the rat-liver one Streptomyces phaeochromogenes ?
-
?