Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.3.99.4 extracted from

  • Kalnins, G.; Kuka, J.; Grinberga, S.; Makrecka-Kuka, M.; Liepinsh, E.; Dambrova, M.; Tars, K.
    Structure and function of CutC choline lyase from human microbiota bacterium Klebsiella pneumoniae (2015), J. Biol. Chem., 290, 21732-21740 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Klebsiella pneumoniae

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop method, crystal structures of both the choline-bound and choline free forms of CutC are determined, binding of choline at the ligand-binding site triggers conformational changes in the enzyme structure. Choline-bound CutC crystals exhibit an orthorhombic lattice and space group P212121 with 8 molecules in the asymmetric unit. CutC crystals without choline exhibited a monoclinic lattice and space group P21 with 4 molecules in the asymmetric unit Klebsiella pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
124000
-
mass spectrometry analysis. The 124-kDa full-length CutC protein is very unstable, with the N-terminal part starting to degrade almost immediately after purification by nickel affinity chromatography Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae A0A0M3KL45
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
choline
-
Klebsiella pneumoniae trimethylamine + acetaldehyde
-
?

Subunits

Subunits Comment Organism
dimer
-
Klebsiella pneumoniae

Synonyms

Synonyms Comment Organism
cutC
-
Klebsiella pneumoniae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
21
-
assay at Klebsiella pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Klebsiella pneumoniae