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Literature summary for 4.3.3.7 extracted from

  • Naqvi, K.F.; Staker, B.L.; Dobson, R.C.; Serbzhinskiy, D.; Sankaran, B.; Myler, P.J.; Hudson, A.O.
    Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 A resolution (2016), Acta Crystallogr. Sect. F, 72, 2-9 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.3.3.7

Cloned(Commentary)

Cloned (Comment) Organism
-
 Bartonella henselae

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting-drop vapor-diffusion Bartonella henselae
sitting-drop vapor-diffusion, protein crystals are grown in conditions consisting of 20%(w/v) PEG 4000, 100 mM sodium citrate tribasic pH 5.5 and diffract to 2.10 A resolution. They belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 79.96, b = 106.33, c = 136.25 A Bartonella henselae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + L-aspartate-4-semialdehyde Bartonella henselae the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?
pyruvate + L-aspartate-4-semialdehyde Bartonella henselae ATCC 49882 the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?
pyruvate + L-aspartate-4-semialdehyde Bartonella henselae Houston 1 the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bartonella henselae Q6G468
-
-
Bartonella henselae ATCC 49882 Q6G468
-
-
Bartonella henselae Houston 1 Q6G468
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bartonella henselae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + L-aspartate-4-semialdehyde
-
 Bartonella henselae (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?
pyruvate + L-aspartate-4-semialdehyde the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis Bartonella henselae (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?
pyruvate + L-aspartate-4-semialdehyde
-
 Bartonella henselae ATCC 49882 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?
pyruvate + L-aspartate-4-semialdehyde the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis Bartonella henselae ATCC 49882 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?
pyruvate + L-aspartate-4-semialdehyde
-
 Bartonella henselae Houston 1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?
pyruvate + L-aspartate-4-semialdehyde the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis Bartonella henselae Houston 1 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?

Subunits

Subunits Comment Organism
tetramer
-
 Bartonella henselae

Synonyms

Synonyms Comment Organism
DapA
-
 Bartonella henselae

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the committed step in the synthesis of diaminopimelate and lysine to facilitate peptidoglycan and protein synthesis Bartonella henselae