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Literature summary for 4.3.3.7 extracted from

  • Dobson, R.C.; Gerrard, J.A.; Pearce, F.G.
    Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde (2004), Biochem. J., 377, 757-762.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
biotechnology enzyme is a target for herbicide and anti-microbial action Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by (S)-aspartate 4-semialdehyde, but inhibition occurs by a derivative that is built of the compounbd in the enzyme preparation by ozonolysis Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
(S)-aspartate 4-semialdehyde pH 8.0, 30°C, with pyruvate Escherichia coli
0.21
-
(R,S)-aspartate-4-semialdehyde pH 8.0, 30°C, with pyruvate Escherichia coli
0.25
-
pyruvate pH 8.0, 30°C, with (S)-aspartate 4-semialdehyde Escherichia coli
0.3
-
pyruvate pH 8.0, 30°C, with (R,S)-aspartate 4-semialdehyde Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31270
-
mass spectrometry Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-aspartate 4-semialdehyde + pyruvate Escherichia coli first step in the biosynthesis of lysine, overview dihydrodipicolinate + H2O
-
?
(S)-aspartate 4-semialdehyde + pyruvate Escherichia coli XL1-Blue first step in the biosynthesis of lysine, overview dihydrodipicolinate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
expressing the enzyme from a plasmid, gene dapA
-
Escherichia coli XL1-Blue
-
expressing the enzyme from a plasmid, gene dapA
-

Purification (Commentary)

Purification (Comment) Organism
enzyme expressed from plasmid in strain XL1-Blue, 69fold Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.11
-
purified enzyme Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-aspartate 4-semialdehyde + pyruvate
-
Escherichia coli dihydrodipicolinate + H2O
-
?
(S)-aspartate 4-semialdehyde + pyruvate first step in the biosynthesis of lysine, overview Escherichia coli dihydrodipicolinate + H2O
-
?
(S)-aspartate 4-semialdehyde + pyruvate
-
Escherichia coli XL1-Blue dihydrodipicolinate + H2O
-
?
(S)-aspartate 4-semialdehyde + pyruvate first step in the biosynthesis of lysine, overview Escherichia coli XL1-Blue dihydrodipicolinate + H2O
-
?
additional information no activity with (R)-aspartate 4-semialdehyde Escherichia coli ?
-
?
additional information no activity with (R)-aspartate 4-semialdehyde Escherichia coli XL1-Blue ?
-
?
pyruvate + (R,S)-aspartate-4-semialdehyde
-
Escherichia coli (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
?
pyruvate + (R,S)-aspartate-4-semialdehyde
-
Escherichia coli XL1-Blue (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
?

Synonyms

Synonyms Comment Organism
DHDPS
-
Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Escherichia coli