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Literature summary for 4.3.2.9 extracted from

  • Yoshiya, T.; Ii, H.; Tsuda, S.; Mochizuki, M.; Kageyama, S.; Yoshiki, T.
    Design of fluorogenic probes and fluorescent-tagged inhibitors for gamma-glutamyl cyclotransferase (2017), J. Pept. Sci., 23, 618-623 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glutaryl-L-Ala 54% inhibition Homo sapiens
N2-(4-carboxybutanoyl)-N6-(7-nitro-2,1,3-benzoxadiazol-4-yl)-L-lysine 53% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.28
-
gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys pH 6.5, temperature not specified in the publication Homo sapiens
0.32
-
gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys pH 8.0, temperature not specified in the publication Homo sapiens
0.38
-
L-gamma-glutamyl-O-[(4-methylumbelliferyl)carbonyl]-L-serine pH 6.5, temperature not specified in the publication Homo sapiens
0.56
-
N5-((S)-1-carboxy-3-(ethyl(((3-oxo-3H-phenoxazin-7-yl)oxy)carbonyl)amino)propyl)-L-glutamine pH 8.0, temperature not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O75223
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys
-
Homo sapiens epsilon-N-benzyloxycarbonyl-L-Lys + 5-oxo-L-proline
-
?
L-gamma-glutamyl-O-[(4-methylumbelliferyl)carbonyl]-L-serine fluorogenic probe Homo sapiens (2S)-2-amino-3-([[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]oxy)propanoic acid + 5-oxo-L-proline
-
?
N5-((S)-1-carboxy-3-(ethyl(((3-oxo-3H-phenoxazin-7-yl)oxy)carbonyl)amino)propyl)-L-glutamine fluorogenic probe Homo sapiens (2S)-2-amino-4-(ethyl[[(3-oxo-3H-phenoxazin-7-yl)oxy]carbonyl]amino)butanoic acid + 5-oxo-L-proline
-
?

Synonyms

Synonyms Comment Organism
C7orf24
-
Homo sapiens
GGCT
-
Homo sapiens