Literature summary for 4.3.2.9 extracted from

  • Bowser, T.E.; Trawick, M.L.
    Probing the specificity of gamma-glutamylamine cyclotransferase: an enzyme involved in the metabolism of transglutaminase-catalyzed protein crosslinks (2013), Amino Acids, 44, 143-150.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045
-
2-amino-5-(cyclopropylamino)-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.1
-
5-L-glutamyl-anilide pH and temperature not specified in the publication Oryctolagus cuniculus
0.26
-
Nepsilon-(5-L-glutamyl)-L-lysine pH and temperature not specified in the publication Oryctolagus cuniculus
0.012
-
2-amino-5-(tert-butylamino)-5-oxopentanoic acid kcat above 0.012 s-1, pH and temperature not specified in the publication Oryctolagus cuniculus
0.21
-
2-amino-5-[[(2S)-2-methylbutyl]amino]-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.07
-
2-amino-5-(butan-2-ylamino)-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.11
-
2-amino-5-[(2S)-butan-2-ylamino]-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.12
-
5-L-glutamyl-neohexylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.25
-
5-L-glutamyl-n-butylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.14
-
5-L-glutamyl-(+)-3-aminobutyric acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.19
-
S-(cyclohexylamine)-L-cysteine pH and temperature not specified in the publication Oryctolagus cuniculus
0.19
-
2-amino-5-[(2-methylbutyl)amino]-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
20
-
O-(n-butylcarbamyl)-L-serine pH and temperature not specified in the publication Oryctolagus cuniculus
0.32
-
5-L-glutamyl-n-propylamine pH and temperature not specified in the publication Oryctolagus cuniculus
1.9
-
5-L-Glutamyl-glycine pH and temperature not specified in the publication Oryctolagus cuniculus
0.33
-
5-L-glutamyl-(+)-3-aminoisobutyric acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.56
-
5-L-glutamyl-benzylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.36
-
5-L-glutamyl-ethylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.061
-
2-amino-5-(cyclohexylamino)-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.27
-
Nepsilon-(5-L-glutamyl)-D-lysine pH and temperature not specified in the publication Oryctolagus cuniculus
0.091
-
S-(n-butylcarbamyl)-L-cysteine pH and temperature not specified in the publication Oryctolagus cuniculus
0.91
-
5-L-glutamyl-beta-alanine pH and temperature not specified in the publication Oryctolagus cuniculus
0.093
-
S-(n-propylcarbamyl)-L-cysteine pH and temperature not specified in the publication Oryctolagus cuniculus
0.61
-
5-L-glutamyl-neopentylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.44
-
5-L-glutamyl-beta-phenethylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.068
-
2-amino-5-oxo-5-(propan-2-ylamino)pentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.084
-
5-L-glutamyl-cyclopentylamine pH and temperature not specified in the publication Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme does not act on L-glutamine, alpha-(5-L-glutamyl)-L-lysine, 5-L-glutamyl-L-methionine, or 5-L-glutamyl-L-glutamine Oryctolagus cuniculus ?
-
?
5-L-glutamyl-glycine poor substrate Oryctolagus cuniculus 5-oxoproline + glycine
-
?
Nepsilon-(5-L-glutamyl)-L-lysine
-
Oryctolagus cuniculus 5-oxoproline + L-lysine
-
?
2-amino-5-(butan-2-ylamino)-5-oxopentanoic acid
-
Oryctolagus cuniculus DL-proline + (S)-butan-2-amine
-
?
2-amino-5-(cyclohexylamino)-5-oxopentanoic acid
-
Oryctolagus cuniculus DL-proline + cyclohexylamine
-
?
2-amino-5-(cyclopropylamino)-5-oxopentanoic acid
-
Oryctolagus cuniculus DL-proline + cyclopropylamine
-
?
2-amino-5-(tert-butylamino)-5-oxopentanoic acid
-
Oryctolagus cuniculus DL-proline + tert-butylamine
-
?
2-amino-5-oxo-5-(propan-2-ylamino)pentanoic acid
-
Oryctolagus cuniculus DL-proline + propan-2-amine
-
?
2-amino-5-[(2-methylbutyl)amino]-5-oxopentanoic acid
-
Oryctolagus cuniculus DL-proline + (RS)-2-methylbutan-1-amine
-
?
2-amino-5-[(2S)-butan-2-ylamino]-5-oxopentanoic acid
-
Oryctolagus cuniculus DL-proline + (S)-butan-2-amine
-
?
2-amino-5-[[(2S)-2-methylbutyl]amino]-5-oxopentanoic acid
-
Oryctolagus cuniculus DL-proline + (2S)-2-methylbutan-1-amine
-
?
5-L-glutamyl-(+)-3-aminobutyric acid
-
Oryctolagus cuniculus 5-oxoproline + (+)-3-aminbutyric acid
-
?
5-L-glutamyl-(+)-3-aminoisobutyric acid
-
Oryctolagus cuniculus 5-oxoproline + (+)-3-aminoisobutyric acid
-
?
5-L-glutamyl-anilide
-
Oryctolagus cuniculus 5-oxoproline + aniline
-
?
5-L-glutamyl-benzylamine
-
Oryctolagus cuniculus 5-oxoproline + benzylamine
-
?
5-L-glutamyl-beta-alanine
-
Oryctolagus cuniculus 5-oxoproline + beta-alanine
-
?
5-L-glutamyl-beta-phenethylamine
-
Oryctolagus cuniculus 5-oxoproline + beta-phenethylamine
-
?
5-L-glutamyl-cyclopentylamine
-
Oryctolagus cuniculus 5-oxoproline + cyclopentylamine
-
?
5-L-glutamyl-ethylamine
-
Oryctolagus cuniculus 5-oxoproline + ethylamine
-
?
5-L-glutamyl-methylamine
-
Oryctolagus cuniculus 5-oxoproline + methylamine
-
?
5-L-glutamyl-n-butylamine
-
Oryctolagus cuniculus 5-oxoproline + butylamine
-
?
5-L-glutamyl-n-propylamine
-
Oryctolagus cuniculus 5-oxoproline + propylamine
-
?
5-L-glutamyl-neohexylamine
-
Oryctolagus cuniculus 5-oxoproline + neohexylamine
-
?
5-L-glutamyl-neopentylamine
-
Oryctolagus cuniculus 5-oxoproline + neopentylamine
-
?
L-2-amino-3-(3-n-butylureido)-propionic acid
-
Oryctolagus cuniculus ?
-
?
Nepsilon-(5-L-glutamyl)-D-lysine
-
Oryctolagus cuniculus ?
-
?
O-(n-butylcarbamyl)-L-serine
-
Oryctolagus cuniculus ?
-
?
S-(cyclohexylamine)-L-cysteine
-
Oryctolagus cuniculus ?
-
?
S-(n-butylcarbamyl)-L-cysteine
-
Oryctolagus cuniculus ?
-
?
S-(n-propylcarbamyl)-L-cysteine
-
Oryctolagus cuniculus ?
-
?

Synonyms

Synonyms Comment Organism
GGACT
-
Oryctolagus cuniculus
gamma-glutamylamine cyclotransferase
-
Oryctolagus cuniculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.17
-
5-L-glutamyl-beta-phenethylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.2
-
Nepsilon-(5-L-glutamyl)-L-lysine pH and temperature not specified in the publication Oryctolagus cuniculus
0.26
-
S-(cyclohexylamine)-L-cysteine pH and temperature not specified in the publication Oryctolagus cuniculus
0.4
-
5-L-glutamyl-benzylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.21
-
5-L-glutamyl-n-butylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.24
-
S-(n-propylcarbamyl)-L-cysteine pH and temperature not specified in the publication Oryctolagus cuniculus
0.036
-
5-L-glutamyl-anilide pH and temperature not specified in the publication Oryctolagus cuniculus
12
-
O-(n-butylcarbamyl)-L-serine pH and temperature not specified in the publication Oryctolagus cuniculus
0.02
-
5-L-glutamyl-methylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.14
-
5-L-Glutamyl-glycine pH and temperature not specified in the publication Oryctolagus cuniculus
0.035
-
5-L-glutamyl-neopentylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.001
-
L-2-amino-3-(3-n-butylureido)-propionic acid kcat below 0.001 s-1, pH and temperature not specified in the publication Oryctolagus cuniculus
0.18
-
5-L-glutamyl-beta-alanine pH and temperature not specified in the publication Oryctolagus cuniculus
0.18
-
5-L-glutamyl-neohexylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.25
-
Nepsilon-(5-L-glutamyl)-D-lysine pH and temperature not specified in the publication Oryctolagus cuniculus
0.038
-
5-L-glutamyl-ethylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.27
-
S-(n-butylcarbamyl)-L-cysteine pH and temperature not specified in the publication Oryctolagus cuniculus
0.071
-
5-L-glutamyl-(+)-3-aminoisobutyric acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.23
-
5-L-glutamyl-n-propylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.054
-
5-L-glutamyl-(+)-3-aminobutyric acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.076
-
5-L-glutamyl-cyclopentylamine pH and temperature not specified in the publication Oryctolagus cuniculus

KCat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.83
-
5-L-glutamyl-n-butylamine pH and temperature not specified in the publication Oryctolagus cuniculus
1.5
-
S-(cyclohexylamine)-L-cysteine pH and temperature not specified in the publication Oryctolagus cuniculus
0.21
-
5-L-glutamyl-(+)-3-aminoisobutyric acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.21
-
2-amino-5-(cyclopropylamino)-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.22
-
2-amino-5-(cyclopropylamino)-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.78
-
Nepsilon-(5-L-glutamyl)-L-lysine pH and temperature not specified in the publication Oryctolagus cuniculus
0.9
-
5-L-glutamyl-cyclopentylamine pH and temperature not specified in the publication Oryctolagus cuniculus
2.8
-
S-(n-butylcarbamyl)-L-cysteine pH and temperature not specified in the publication Oryctolagus cuniculus
0.11
-
5-L-glutamyl-ethylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.72
-
5-L-glutamyl-n-propylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.55
-
2-amino-5-[[(2S)-2-methylbutyl]amino]-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.066
-
2-amino-5-[(2S)-butan-2-ylamino]-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.19
-
5-L-glutamyl-beta-alanine pH and temperature not specified in the publication Oryctolagus cuniculus
0.19
-
5-L-glutamyl-anilide pH and temperature not specified in the publication Oryctolagus cuniculus
0.19
-
2-amino-5-(cyclohexylamino)-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
2.6
-
S-(n-propylcarbamyl)-L-cysteine pH and temperature not specified in the publication Oryctolagus cuniculus
0.32
-
2-amino-5-(cyclohexylamino)-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.057
-
5-L-glutamyl-neopentylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.38
-
5-L-glutamyl-beta-phenethylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.38
-
2-amino-5-[[(2S)-2-methylbutyl]amino]-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.38
-
2-amino-5-[(2-methylbutyl)amino]-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.69
-
2-amino-5-oxo-5-(propan-2-ylamino)pentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.6
-
O-(n-butylcarbamyl)-L-serine pH and temperature not specified in the publication Oryctolagus cuniculus
0.71
-
5-L-glutamyl-benzylamine pH and temperature not specified in the publication Oryctolagus cuniculus
0.097
-
2-amino-5-oxo-5-(propan-2-ylamino)pentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.51
-
2-amino-5-[(2-methylbutyl)amino]-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.92
-
Nepsilon-(5-L-glutamyl)-D-lysine pH and temperature not specified in the publication Oryctolagus cuniculus
0.058
-
2-amino-5-(butan-2-ylamino)-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
0.071
-
5-L-Glutamyl-glycine pH and temperature not specified in the publication Oryctolagus cuniculus
1.45
-
5-L-glutamyl-neohexylamine pH and temperature not specified in the publication Oryctolagus cuniculus
1.62
-
2-amino-5-[(2S)-butan-2-ylamino]-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus
1.24
-
2-amino-5-(butan-2-ylamino)-5-oxopentanoic acid pH and temperature not specified in the publication Oryctolagus cuniculus