Application | Comment | Organism |
---|---|---|
additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Bacillus subtilis |
additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Homo sapiens |
additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Thermotoga maritima |
additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Pyrobaculum aerophilum |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Bacillus subtilis |
- |
Thermotoga maritima |
- |
Pyrobaculum aerophilum |
Protein Variants | Comment | Organism |
---|---|---|
D422Y | mutant without enzyme activity | Homo sapiens |
D430N | mutant without enzyme activity | Homo sapiens |
L423V | mutant without enzyme activity | Homo sapiens |
P110A/D422Y | heat sensitive mutant | Homo sapiens |
R141W | thermostable mutant with decreased activity | Homo sapiens |
R303C | thermostable mutant with decreased activity | Homo sapiens |
R426H | mutant without enzyme activity | Homo sapiens |
S395R | thermostable mutant with decreased activity | Homo sapiens |
S438P | heat sensitive mutant without enzyme activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Bacillus subtilis | |
additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Homo sapiens | |
additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Pyrobaculum aerophilum | |
additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Thermotoga maritima | |
nonenal | - |
Bacillus subtilis | |
nonenal | - |
Homo sapiens | |
nonenal | - |
Pyrobaculum aerophilum | |
nonenal | - |
Thermotoga maritima | |
trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Bacillus subtilis | |
trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Homo sapiens | |
trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Pyrobaculum aerophilum | |
trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Thermotoga maritima |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Bacillus subtilis | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Homo sapiens | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Thermotoga maritima | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Pyrobaculum aerophilum | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
adenylosuccinate | Bacillus subtilis | - |
AMP + fumarate | - |
? | |
adenylosuccinate | Homo sapiens | - |
AMP + fumarate | - |
? | |
adenylosuccinate | Thermotoga maritima | - |
AMP + fumarate | - |
? | |
adenylosuccinate | Pyrobaculum aerophilum | - |
AMP + fumarate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Homo sapiens | - |
- |
- |
Pyrobaculum aerophilum | - |
- |
- |
Thermotoga maritima | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Bacillus subtilis | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Homo sapiens | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Thermotoga maritima | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Pyrobaculum aerophilum | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
adenylosuccinate | - |
Bacillus subtilis | AMP + fumarate | - |
? | |
adenylosuccinate | - |
Homo sapiens | AMP + fumarate | - |
? | |
adenylosuccinate | - |
Thermotoga maritima | AMP + fumarate | - |
? | |
adenylosuccinate | - |
Pyrobaculum aerophilum | AMP + fumarate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Bacillus subtilis |
homotetramer | - |
Homo sapiens |
homotetramer | - |
Thermotoga maritima |
homotetramer | - |
Pyrobaculum aerophilum |
Synonyms | Comment | Organism |
---|---|---|
ADSL | - |
Bacillus subtilis |
ADSL | - |
Thermotoga maritima |
ADSL | - |
Pyrobaculum aerophilum |