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Literature summary for 4.3.2.2 extracted from
- Mammalian adenylosuccinate lyase. Participation in the conversion of 2 -dIMP and beta-D-arabinosyl-IMP to adenine nucleotides (1977), Biochim. Biophys. Acta, 481, 741-745.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2'-deoxy-AMP | competitive | Mus musculus |  |
| ADP | weak, competitive | Mus musculus | |
| AMP | - |
Mus musculus | |
| arabinosyl-AMP | beta-D-arabinosyl-AMP, competitive | Mus musculus | |
| ATP | weak, competitive | Mus musculus | |
| Mg2+ | concentration of Mg2+ approaching that of EDTA | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
2'-deoxy-succino-AMP | - |
Mus musculus | |
| 0.0047 | - |
N6-(1,2-dicarboxyethyl)AMP | - |
Mus musculus | |
| 0.0056 | - |
arabinosyl-succino-AMP | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2'-deoxy-succino-AMP | - |
Mus musculus | 2'-deoxy-AMP + fumarate | - |
? | |
| arabinosyl-succino-AMP | i.e. beta-D-arabinosyladenylosuccinate | Mus musculus | arabinosyl-AMP + ? | beta-D-arabinosyl-AMP | ? | |
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