BRENDA - Enzyme Database
show all sequences of 4.3.2.1

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

Zheng, L.; Mackenzie, E.D.; Karim, S.A.; Hedley, A.; Blyth, K.; Kalna, G.; Watson, D.G.; Szlosarek, P.; Frezza, C.; Gottlieb, E.; Cancer Metab. 1, 12 (2013)

Data extracted from this reference:

Application
Application
Commentary
Organism
diagnostics
the urea cycle metabolite argininosuccinate is a common metabolic biomarker of FH deficiency
Homo sapiens
diagnostics
the urea cycle metabolite argininosuccinate is a common metabolic biomarker of FH deficiency
Mus musculus
medicine
loss of function of fumarate hydratase, the mitochondrial tumor suppressor and tricarboxylic acid cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer The accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells from Fh1-deficient humans, making these cells auxotrophic for arginine, which opens a therapeutic perspective for the cure of hereditary leiomyomatosis and renal cell cancer
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
fumarate + L-arginine
Mus musculus
accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
2-(Nomega-L-arginino)succinate
-
-
r
fumarate + L-arginine
Homo sapiens
accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
2-(Nomega-L-arginino)succinate
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Homo sapiens
-
kidney
-
Mus musculus
-
kidney cancer cell
-
Homo sapiens
-
kidney cancer cell
-
Mus musculus
-
UOK-262 cell
fumarate hydratase defiecient or proficient cells, the latter termed UOKpFH cells
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-(Nomega-L-arginino)succinate
-
729518
Mus musculus
fumarate + L-arginine
-
-
-
r
2-(Nomega-L-arginino)succinate
-
729518
Homo sapiens
fumarate + L-arginine
-
-
-
r
fumarate + L-arginine
accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
729518
Mus musculus
2-(Nomega-L-arginino)succinate
-
-
-
r
fumarate + L-arginine
accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
729518
Homo sapiens
2-(Nomega-L-arginino)succinate
-
-
-
r
Application (protein specific)
Application
Commentary
Organism
diagnostics
the urea cycle metabolite argininosuccinate is a common metabolic biomarker of FH deficiency
Homo sapiens
diagnostics
the urea cycle metabolite argininosuccinate is a common metabolic biomarker of FH deficiency
Mus musculus
medicine
loss of function of fumarate hydratase, the mitochondrial tumor suppressor and tricarboxylic acid cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer The accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells from Fh1-deficient humans, making these cells auxotrophic for arginine, which opens a therapeutic perspective for the cure of hereditary leiomyomatosis and renal cell cancer
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
fumarate + L-arginine
Mus musculus
accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
2-(Nomega-L-arginino)succinate
-
-
r
fumarate + L-arginine
Homo sapiens
accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
2-(Nomega-L-arginino)succinate
-
-
r
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Homo sapiens
-
kidney
-
Mus musculus
-
kidney cancer cell
-
Homo sapiens
-
kidney cancer cell
-
Mus musculus
-
UOK-262 cell
fumarate hydratase defiecient or proficient cells, the latter termed UOKpFH cells
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-(Nomega-L-arginino)succinate
-
729518
Mus musculus
fumarate + L-arginine
-
-
-
r
2-(Nomega-L-arginino)succinate
-
729518
Homo sapiens
fumarate + L-arginine
-
-
-
r
fumarate + L-arginine
accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
729518
Mus musculus
2-(Nomega-L-arginino)succinate
-
-
-
r
fumarate + L-arginine
accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
729518
Homo sapiens
2-(Nomega-L-arginino)succinate
-
-
-
r
General Information
General Information
Commentary
Organism
malfunction
argininosuccinate aciduria is observed in patients deficient in the enzyme. An increase in aspartate- and citrulline-derived argininosuccinate is a consequence of enzyme inhibition by high levels of fumarate in fumarate hydratase-deficient cells. In these cells, argininosuccinate is not produced from citrulline and aspartate in FH-deficient cells but rather from arginine and fumarate
Homo sapiens
malfunction
an increase in aspartate- and citrulline-derived argininosuccinate is a consequence of enzyme inhibition by high levels of fumarate in fumarate hydratase-deficient cells. In these cells, argininosuccinate is not produced from citrulline and aspartate in FH-deficient cells but rather from arginine and fumarate
Mus musculus
additional information
depleting arginine from the growth media by the addition of pegylated arginine deiminase decreases the production of argininosuccinate in FH-deficient cells and reduces cell survival and proliferation
Homo sapiens
additional information
depleting arginine from the growth media by the addition of pegylated arginine deiminase decreases the production of argininosuccinate in FH-deficient cells and reduces cell survival and proliferation
Mus musculus
physiological function
loss of function of fumarate hydratase, the mitochondrial tumor suppressor and tricarboxylic acid cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells from Fh1-deficient humans, making these cells auxotrophic for arginine, which opens a therapeutic perspective for the cure of hereditary leiomyomatosis and renal cell cancer. The urea cycle metabolite argininosuccinate is a common metabolic biomarker of FH deficiency
Homo sapiens
physiological function
loss of function of fumarate hydratase, the mitochondrial tumor suppressor and tricarboxylic acid cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells from Fh1-deficient mice, making these cells auxotrophic for arginine
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
argininosuccinate aciduria is observed in patients deficient in the enzyme. An increase in aspartate- and citrulline-derived argininosuccinate is a consequence of enzyme inhibition by high levels of fumarate in fumarate hydratase-deficient cells. In these cells, argininosuccinate is not produced from citrulline and aspartate in FH-deficient cells but rather from arginine and fumarate
Homo sapiens
malfunction
an increase in aspartate- and citrulline-derived argininosuccinate is a consequence of enzyme inhibition by high levels of fumarate in fumarate hydratase-deficient cells. In these cells, argininosuccinate is not produced from citrulline and aspartate in FH-deficient cells but rather from arginine and fumarate
Mus musculus
additional information
depleting arginine from the growth media by the addition of pegylated arginine deiminase decreases the production of argininosuccinate in FH-deficient cells and reduces cell survival and proliferation
Homo sapiens
additional information
depleting arginine from the growth media by the addition of pegylated arginine deiminase decreases the production of argininosuccinate in FH-deficient cells and reduces cell survival and proliferation
Mus musculus
physiological function
loss of function of fumarate hydratase, the mitochondrial tumor suppressor and tricarboxylic acid cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells from Fh1-deficient humans, making these cells auxotrophic for arginine, which opens a therapeutic perspective for the cure of hereditary leiomyomatosis and renal cell cancer. The urea cycle metabolite argininosuccinate is a common metabolic biomarker of FH deficiency
Homo sapiens
physiological function
loss of function of fumarate hydratase, the mitochondrial tumor suppressor and tricarboxylic acid cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate leads to reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells from Fh1-deficient mice, making these cells auxotrophic for arginine
Mus musculus
Other publictions for EC 4.3.2.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747996
Mishra
Biochemical characterization ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
IUBMB Life
69
896-907
2017
-
-
1
-
2
-
1
2
-
-
1
2
-
3
-
-
-
-
-
-
-
-
4
1
1
-
3
2
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
1
-
2
-
-
1
2
-
-
-
-
-
-
-
-
4
1
1
-
3
2
1
-
-
-
-
1
1
-
2
2
748796
Hung
Argininosuccinate lyase inter ...
Homo sapiens
Oncol. Rep.
37
969-978
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
748357
Hu
Unstable argininosuccinate ly ...
Homo sapiens
J. Inherit. Metab. Dis.
38
815-827
2015
-
-
1
-
6
-
-
6
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
7
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
6
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
7
-
-
-
-
-
-
3
3
-
-
-
748794
Huang
Argininosuccinate lyase is a ...
Homo sapiens
Oncol. Rep.
34
3131-3139
2015
-
3
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728938
Premkumar
Argininosuccinate lyase in ent ...
Mus musculus, Rattus norvegicus
Am. J. Physiol. Gastrointest. Liver Physiol.
307
G347-G354
2014
-
2
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
730344
Han
In vivo-induced argininosuccin ...
Mus musculus, Mus musculus BALB/c
Microbiology
160
567-575
2014
-
1
1
-
1
-
-
-
-
-
-
-
-
61
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
730616
Xia
Normal root elongation require ...
Oryza sativa
Plant J.
78
215-226
2014
-
-
1
-
2
-
-
-
2
-
-
-
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
728906
Paul
Cloning, expression, purificat ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. F
69
1422-1424
2013
-
-
1
1
-
-
-
-
-
-
1
-
-
3
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
729518
Zheng
Reversed argininosuccinate lya ...
Homo sapiens, Mus musculus
Cancer Metab.
1
12
2013
-
3
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
5
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
5
-
-
4
-
-
-
-
-
-
-
-
-
-
6
6
-
-
-
715811
Engel
Bacterial expression of mutant ...
Homo sapiens
J. Inherit. Metab. Dis.
35
133-140
2012
-
1
1
-
1
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
8
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
8
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
713670
Cao
Crystallization and preliminar ...
Streptococcus mutans
Acta Crystallogr. Sect. F
67
682-684
2011
-
-
1
1
-
-
-
-
-
-
2
-
-
5
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714375
Chen
Distinct interactions of alpha ...
Homo sapiens
Biochimie
93
314-320
2011
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
1
1
-
-
-
730448
Erez
Requirement of argininosuccina ...
Homo sapiens, Mus musculus
Nat. Med.
17
1619-1626
2011
-
1
1
-
2
-
-
-
2
-
-
2
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
6
6
-
-
-
707078
Chen
In vivo renal arginine release ...
Rattus norvegicus
Am. J. Physiol. Renal Physiol.
298
F95-102
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709964
Mercimek-Mahmutoglu
Long-term outcome of patients ...
Homo sapiens
Mol. Genet. Metab.
100
24-28
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
710057
Chen
Effects of angiotensin type 1 ...
Rattus norvegicus
Nephrol. Dial. Transplant.
25
3518-3525
2010
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710563
Zhao
Regulation of cellular metabol ...
Homo sapiens
Science
327
1000-1004
2010
1
-
1
-
1
-
2
-
-
-
-
1
-
2
-
1
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
2
-
-
-
-
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697084
Lam
Recombinant human arginase inh ...
Homo sapiens
Cancer Lett.
277
91-100
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698188
Mitchell
Genetic variation in the urea ...
Homo sapiens
Hum. Mutat.
30
56-60
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699254
Laberge
Effects of crowding on ornithi ...
Opsanus beta
J. Exp. Biol.
212
2394-2402
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
705506
Nagasaka
Evaluation of endogenous nitri ...
Homo sapiens
Metab. Clin. Exp.
58
278-282
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
708319
Swamy
Nitric oxide (NO), citrulline- ...
Rattus norvegicus
Drug Chem. Toxicol.
32
326-331
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709062
Trevisson
Functional complementation in ...
Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
284
28926-28934
2009
-
-
-
-
12
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709968
Neill
Quantitative RT-PCR comparison ...
Homo sapiens
Mol. Genet. Metab.
97
121-127
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
11
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
11
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
710663
Sharma
Alterations in lung arginine m ...
Ovis aries
Vascul. Pharmacol.
51
359-364
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
698510
Takagi
Changes of activity and mRNA e ...
Bos taurus
J. Anim. Sci.
86
1526-1532
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699183
Feng
Study of serum argininosuccina ...
Homo sapiens
J. Clin. Lab. Anal.
22
220-227
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699983
Levillain
L-Arginine metabolism in dog k ...
Canis lupus familiaris
Metab. Clin. Exp.
57
9-23
2008
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700039
Bringel
Lactobacillus plantarum respon ...
Lactobacillus plantarum
Microbiology
154
2629-2640
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
700333
Eastwood
Hairpin-mediated down-regulati ...
Agaricus bisporus
Mycol. Res.
112
708-716
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673486
Bizzoco
Transient ischemia increases n ...
Rattus norvegicus
Exp. Neurol.
204
252-259
2007
-
1
-
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676120
Wagemaker
Argininosuccinate synthetase a ...
Agaricus bisporus
Mycol. Res.
111
493-502
2007
-
-
1
-
-
-
-
-
-
-
1
1
-
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679695
Bizzoco
Activated microglia cells expr ...
Rattus norvegicus
Exp. Neurol.
208
100-109
2007
-
1
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679780
Tischner
Interference with the citrulli ...
Arabidopsis thaliana
FEBS J.
274
4238-4245
2007
-
-
-
-
-
-
1
1
-
-
-
1
-
3
-
-
1
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
1
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664119
Tsai
Recovery of argininosuccinate ...
Anas sp.
Biochemistry
44
9034-9044
2005
-
-
1
-
17
-
-
16
-
-
-
1
-
2
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
17
-
-
-
-
16
-
-
-
1
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666202
Yim
-
Molecular cloning and analysis ...
Corynebacterium glutamicum
Korean J. Genet.
27
25-33
2005
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663485
Bhaumik
Structure determination and re ...
Escherichia coli
Acta Crystallogr. Sect. D
60
1964-1970
2004
-
-
1
1
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664011
Tsai
A duck delta1 crystallin doubl ...
Anas sp.
Biochemistry
43
11672-11682
2004
-
-
1
1
1
-
-
-
-
-
-
1
-
3
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651195
Van Geldre
L-citrulline recycling by argi ...
Rattus norvegicus
Eur. J. Pharmacol.
455
149-160
2002
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652321
Sampaleanu
Mutational analysis of duck de ...
Anas platyrhynchos
J. Biol. Chem.
277
4166-4175
2002
-
-
1
1
-
-
-
-
1
-
-
1
-
2
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650042
Sampaleanu
Three-dimensional structure of ...
Homo sapiens
Biochemistry
40
15570-15580
2001
-
-
1
1
2
-
-
1
-
-
-
1
-
4
-
-
1
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
1
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
650043
Yu
Mechanisms for intragenic comp ...
Homo sapiens
Biochemistry
40
15581-15590
2001
-
-
1
-
4
-
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
1
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
650920
Troshina
Cloning, characterization, and ...
Nostoc sp.
Curr. Microbiol.
43
260-264
2001
-
-
1
-
-
-
-
-
-
-
2
1
-
5
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650800
Yu
Intragenic complementation and ...
Homo sapiens
Cell. Mol. Life Sci.
57
1637-1651
2000
-
-
-
-
-
1
2
3
1
-
1
1
-
1
-
-
1
-
-
8
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
3
1
-
1
1
-
-
-
1
-
8
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652664
Latasa
Identification of argininosucc ...
Rattus norvegicus
J. Hepatol.
33
709-715
2000
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652692
Linnebank
Two novel mutations (E86A, R11 ...
Homo sapiens
J. Inherit. Metab. Dis.
23
308-312
2000
-
-
1
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653358
Daniel
Arginosuccinate synthetase, ar ...
Canis lupus familiaris
Neurogastroenterol. Motil.
12
317-334
2000
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34438
Auchincloss
The argininosuccinate lyase ge ...
Chlamydomonas reinhardtii
Mol. Gen. Genet.
261
21-30
1999
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34447
Chakraborty
Mutational analysis of amino a ...
Anas platyrhynchos, Homo sapiens
Biochemistry
38
2435-2443
1999
-
-
-
-
8
-
-
6
-
-
-
-
-
5
-
-
-
1
-
3
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
6
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
650743
Braissant
L-arginine uptake, the citrull ...
Rattus norvegicus
Brain Res. Mol. Brain Res.
70
231-241
1999
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651343
Cohen-Kupiec
Functional conservation betwee ...
Methanococcus maripaludis
FEMS Microbiol. Lett.
173
231-238
1999
-
-
1
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34436
Wu
Chemical mechanism of the endo ...
Anas platyrhynchos
Biochem. J.
333
327-334
1998
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
1
-
2
-
-
3
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
34437
Piatigorsky
Characterization and enzyme ac ...
Anas platyrhynchos
Biochim. Biophys. Acta
1295
158-164
1996
-
-
-
-
-
-
-
4
-
-
-
-
-
5
-
-
-
-
-
3
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
34441
Turner
Expression, purification, crys ...
Homo sapiens
J. Mol. Biol.
239
336-338
1994
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34445
Lee
Characterization of the multip ...
Anas platyrhynchos
Arch. Biochem. Biophys.
314
31-38
1994
-
-
-
-
-
-
-
10
-
-
1
-
-
3
-
1
-
-
-
2
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
1
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
34443
Voorter
delta-Crystallin is more therm ...
Anas platyrhynchos, Bos taurus, Sus scrofa
Exp. Eye Res.
56
733-735
1993
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
3
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
3
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
34446
Lee
Inactivation of the endogenous ...
Anas platyrhynchos
Biochem. J.
293
537-544
1993
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34440
Kondoh
Expression of the chicken delt ...
Gallus gallus
Gene
99
267-271
1991
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34442
Chiou
Screening and kinetic analysis ...
Anas platyrhynchos, Anser sp., Gallus gallus
Biochem. Int.
25
705-713
1991
-
-
-
-
-
-
-
2
-
-
2
-
-
10
-
-
-
3
-
3
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
3
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
34444
Barbosa
-
Expression of duck lens delta- ...
Anas platyrhynchos
J. Biol. Chem.
266
2319-2322
1991
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725629
Van de Casteele
-
Pathways of arginine biosynthe ...
Pyrococcus furiosus, Saccharolobus solfataricus, Saccharolobus solfataricus P1
J. Gen. Microbiol.
136
1177-1183
1990
-
-
-
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
34439
Matsubasa
Structure of the rat argininos ...
Gallus gallus, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
86
592-596
1989
-
-
1
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34419
Matuo
Isolation of cDNA clones of hu ...
Homo sapiens
FEBS Lett.
234
395-399
1988
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34420
Miura
An enzymatic method for the as ...
Homo sapiens, Sus scrofa
Anal. Biochem.
164
482-487
1987
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34421
Lusty
Reaction of argininosuccinase ...
Bos taurus
Proc. Natl. Acad. Sci. USA
84
3176-3180
1987
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34422
Farrell
Characterization of argininosu ...
Chlamydomonas reinhardtii
Biochem. J.
242
261-266
1987
-
-
-
-
-
-
-
1
-
-
2
-
-
7
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34423
O'Brien
Cloning and sequence analysis ...
Homo sapiens, Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
83
7211-7215
1986
-
-
-
-
-
-
-
-
-
-
2
-
-
4
-
-
-
-
-
2
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34424
Garrard
Acid-base catalysis in the arg ...
Bos taurus
J. Biol. Chem.
260
5548-5553
1985
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1588
Raushel
Nitro analogs of substrates fo ...
Bos taurus
Arch. Biochem. Biophys.
232
520-525
1984
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34426
Garred
Substrate-induced inactivation ...
Bos taurus
Biochemistry
22
3729-3735
1983
-
-
-
-
-
-
3
3
-
-
-
-
-
2
-
-
-
-
-
2
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
-
2
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34427
Raushel
Kinetic mechanism of bovine li ...
Bos taurus
Arch. Biochem. Biophys.
221
143-147
1983
-
-
-
-
-
-
4
-
-
-
-
-
-
2
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34428
Palekar
Human liver arginiosuccinase p ...
Homo sapiens
J. Biol. Chem.
256
9192-9194
1981
-
-
-
-
-
-
-
1
-
-
2
-
-
3
-
-
1
-
-
2
1
1
1
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
2
1
1
1
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
34429
O'Brien
Argininosuccinate lyase: purif ...
Homo sapiens
Biochemistry
20
2056-2060
1981
-
-
-
-
-
1
-
3
-
-
2
-
-
5
-
-
1
-
-
2
2
1
2
1
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
3
-
-
2
-
-
-
-
1
-
2
2
1
2
1
-
-
-
-
2
-
2
-
-
-
-
-
-
-
34430
Murakami-Murofushi
Argininosuccinase from bovine ...
Bos taurus
Anal. Biochem.
95
139-155
1979
-
-
-
-
-
1
1
1
-
-
2
-
-
2
-
-
1
-
-
4
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
2
-
-
-
-
1
-
4
1
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34431
Matagne
Purification and subunit struc ...
Chlamydomonas reinhardtii
Biochem. J.
167
71-75
1977
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
1
-
-
-
1
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
1
-
-
1
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34432
Menyhart
Urea as a selective inhibitor ...
Rattus norvegicus
Eur. J. Biochem.
75
405-409
1977
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34433
Rochovansky
On the role of substrate and G ...
Bos taurus
J. Biol. Chem.
250
7225-72300
1975
1
-
-
-
-
-
-
2
-
-
-
1
-
3
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34434
Lusty
Biosynthesis of urea. XIV. The ...
Bos taurus
J. Biol. Chem.
247
7010-7022
1972
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34435
Bray
Argininosuccinase from bovine ...
Bos taurus
Arch. Biochem. Biophys.
146
531-541
1971
-
-
-
1
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
3
-
-
-
-
-
-
-
1
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-