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Literature summary for 4.3.1.7 extracted from

  • Bender, G.; Poyner, R.R.; Reed, G.H.
    Identification of the substrate radical intermediate derived from ethanolamine during catalysis by ethanolamine ammonia-lyase (2008), Biochemistry, 47, 11360-11366.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

Inhibitors Comment Organism Structure
hydroxyethylhydrazine the latter suicide inhibitor effects a stoichiometric conversion of enzyme-bound adenosylcobalamin into its cleaved form cob(II)alamin Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ included in the cofactor B12 Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
beta-subunit Salmonella enterica subsp. enterica serovar Typhimurium
50000
-
alpha-subunit Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ethanolamine Salmonella enterica subsp. enterica serovar Typhimurium elimination of ammonia from the vicinal position of short chain amino alcohol to give the corresponding oxo product acetaldehyde + NH3
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
specific activity is 30-45 micromol ethanolamine/min/mg of EAL at 25°C, determined by the EAL-alcohol dehydrogenase coupled assay Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethanolamine elimination of ammonia from the vicinal position of short chain amino alcohol to give the corresponding oxo product Salmonella enterica subsp. enterica serovar Typhimurium acetaldehyde + NH3
-
?

Subunits

Subunits Comment Organism
hexamer functional protein is a hexamer of alpha-beta-dimers (alpha-subunit of 50000 Da and beta-subunit of 31000 Da) Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

Synonyms Comment Organism
EAL
-
Salmonella enterica subsp. enterica serovar Typhimurium
ethanolamine ammonia-lyase
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Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
coenzyme B12 adenosylcobalamin, 70% of the enzyme-bound adenosylcobalamin is cleaved to cob(2)-alamin in the steady state of the reaction Salmonella enterica subsp. enterica serovar Typhimurium