Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor | Streptomyces venezuelae | key reaction in the biosynthesis of TDP-desosamine, which is an essential component of many macrolide antibiotics | dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces venezuelae | Q9ZGH1 | - |
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Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor | key reaction in the biosynthesis of TDP-desosamine, which is an essential component of many macrolide antibiotics | Streptomyces venezuelae | dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor | - |
? | |
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor | the radical S-adenosylmethionine enzyme catalyzes the C4-deamination of TDP-4-amino-4,6-dideoxyglucose through a C3 radical intermediate. If the C4 amino group is replaced with a hydroxy group (to give TDP-quinovose), the hydroxy group at C3 is oxidized to a ketone with no C4-dehydration | Streptomyces venezuelae | dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor | - |
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Synonyms | Comment | Organism |
---|---|---|
DesII | - |
Streptomyces venezuelae |
General Information | Comment | Organism |
---|---|---|
metabolism | key reaction in the biosynthesis of TDP-desosamine, which is an essential component of many macrolide antibiotics | Streptomyces venezuelae |