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Literature summary for 4.3.1.3 extracted from

  • Katona, A.; Tosa, M.I.; Paizs, C.; Retey, J.
    Inhibition of histidine ammonia lyase by heteroaryl-alanines and acrylates (2006), Chem. Biodivers., 3, 502-508.
    View publication on PubMed
Search for more literature for 4.3.1.3

Cloned(Commentary)

Cloned (Comment) Organism
into the pT7-7 vector for expression in Escherichia coli BL21DE3 cells Pseudomonas putida

Inhibitors

Inhibitors Comment Organism Structure
(2E)-3-(1-benzofuran-2-yl)prop-2-enoic acid
-
 Pseudomonas putida
(2E)-3-(1-benzofuran-3-yl)prop-2-enoic acid
-
 Pseudomonas putida
(2E)-3-(1-benzothiophen-2-yl)prop-2-enoic acid
-
 Pseudomonas putida
(2E)-3-(1-benzothiophen-3-yl)prop-2-enoic acid
-
 Pseudomonas putida
(2E)-3-(1-methyl-1H-indol-3-yl)prop-2-enoic acid
-
 Pseudomonas putida
(2E)-3-(1H-indol-3-yl)prop-2-enoic acid
-
 Pseudomonas putida
(2E)-3-(3-methylfuran-2-yl)prop-2-enoic acid
-
 Pseudomonas putida
(2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid
-
 Pseudomonas putida
(2E)-3-furan-2-ylprop-2-enoic acid
-
 Pseudomonas putida
(2E)-3-thiophen-2-ylprop-2-enoic acid
-
 Pseudomonas putida
1-Methyltryptophan
-
 Pseudomonas putida
3-(1-benzofuran-2-yl)alanine
-
 Pseudomonas putida
3-(1-benzofuran-3-yl)alanine
-
 Pseudomonas putida
3-(1-benzothiophen-2-yl)alanine
-
 Pseudomonas putida
3-(1-benzothiophen-3-yl)alanine
-
 Pseudomonas putida
3-(3-methylthiophen-2-yl)alanine
-
 Pseudomonas putida
3-furan-2-ylalanine
-
 Pseudomonas putida
3-thiophen-2-ylalanine
-
 Pseudomonas putida
norhistidine
-
 Pseudomonas putida
tryptophan
-
 Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine Pseudomonas putida
-
 urocanate + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas putida
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Pseudomonas putida

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine
-
 Pseudomonas putida urocanate + NH3
-
 ?

Synonyms

Synonyms Comment Organism
HAL
-
 Pseudomonas putida
histidine ammonia-lyase
-
 Pseudomonas putida

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 activity assay Pseudomonas putida

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.3
-
 activity assay Pseudomonas putida

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.015
-
 (2E)-3-(1H-indol-3-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
0.018
-
 (2E)-3-(3-methylfuran-2-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
0.023
-
 (2E)-3-(1-benzofuran-3-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
0.025
-
 3-(1-benzofuran-2-yl)alanine competitive inhibition Pseudomonas putida
0.026
-
 (2E)-3-(1-methyl-1H-indol-3-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
0.031
-
 1-Methyltryptophan mixed inhibition Pseudomonas putida
0.033
-
 (2E)-3-furan-2-ylprop-2-enoic acid competitive inhibition Pseudomonas putida
0.039
-
 (2E)-3-(1-benzothiophen-2-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
0.04
-
 (2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
0.041
-
 (2E)-3-thiophen-2-ylprop-2-enoic acid competitive inhibition Pseudomonas putida
0.05
-
 tryptophan mixed inhibition Pseudomonas putida
0.053
-
 (2E)-3-(1-benzothiophen-3-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
0.056
-
 (2E)-3-(1-benzofuran-2-yl)prop-2-enoic acid competitive inhibition Pseudomonas putida
0.067
-
 3-(1-benzofuran-3-yl)alanine competitive inhibition Pseudomonas putida
0.082
-
 3-(1-benzothiophen-3-yl)alanine competitive inhibition Pseudomonas putida
0.083
-
 3-(1-benzothiophen-2-yl)alanine competitive inhibition Pseudomonas putida
0.098
-
 3-(3-methylthiophen-2-yl)alanine competitive inhibition Pseudomonas putida
0.101
-
 3-thiophen-2-ylalanine competitive inhibition Pseudomonas putida
0.139
-
 3-furan-2-ylalanine competitive inhibition Pseudomonas putida
1.72
-
 norhistidine mixed inhibition Pseudomonas putida