BRENDA - Enzyme Database
show all sequences of 4.3.1.3

Histidine ammonia-lyase (Pseudomonas)

Rechler, M.M.; Tabor, H.; Methods Enzymol. 17B, 63-69 (1971)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
2-mercaptoethanol
activates
Pseudomonas sp.
dithiothreitol
activates
Pseudomonas sp.
GSH
activates
Pseudomonas sp.
Inhibitors
Inhibitors
Commentary
Organism
Structure
biguanide
-
Pseudomonas sp.
bisulfite
sodiumbisulfite
Pseudomonas sp.
bisulfite
-
Pseudomonas putida
CN-
KCN
Pseudomonas putida
CN-
KCN
Pseudomonas sp.
EDTA
-
Pseudomonas putida
EDTA
-
Pseudomonas sp.
hydroxylamine
-
Pseudomonas sp.
L-cysteine
-
Pseudomonas putida
L-cysteine
-
Pseudomonas sp.
L-tyrosine
heat-purified enzyme, at low concentrations, pH 7-8
Pseudomonas sp.
NaBH4
-
Pseudomonas sp.
p-hydroxyphenylpyruvate
heat-purified enzyme, at low concentrations, pH 7-8
Pseudomonas sp.
p-mercuribenzoate
inhibits mercaptoethanol-activated enzyme
Pseudomonas sp.
phenylhydrazine
-
Pseudomonas sp.
Sodium diphosphate
-
Pseudomonas sp.
Urocanate
-
Pseudomonas aeruginosa
Urocanate
heat-purified enzyme, at low concentrations, pH 7-8
Pseudomonas sp.
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.8
-
L-histidine
25°C
Pseudomonas sp.
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mn2+
enhances activity
Pseudomonas sp.
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
210000
-
-
Pseudomonas aeruginosa
210000
-
sedimentation equilibrium
Pseudomonas sp.
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pseudomonas aeruginosa
-
-
-
Pseudomonas putida
-
-
-
Pseudomonas sp.
-
ATCC 11,299b
-
Purification (Commentary)
Commentary
Organism
-
Pseudomonas sp.
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Pseudomonas putida
additional information
-
-
Pseudomonas sp.
Storage Stability
Storage Stability
Organism
2°C, 0.1 M potassium phosphate, pH 7.2, 0.1 mM MnCl2 saturated with chloroform, stable for 9 months without loss of activity
Pseudomonas sp.
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-histidine
natural substrate
34278
Pseudomonas aeruginosa
urocanate + NH3
-
34278
Pseudomonas aeruginosa
?
L-histidine
natural substrate
34278
Pseudomonas sp.
urocanate + NH3
-
34278
Pseudomonas sp.
?
L-histidine
natural substrate
34278
Pseudomonas putida
urocanate + NH3
-
34278
Pseudomonas putida
-
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
-
Pseudomonas sp.
pH Range
pH Minimum
pH Maximum
Commentary
Organism
8.1
9.9
50% of maximal activity at pH 8.1 and pH 9.9
Pseudomonas sp.
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
2-mercaptoethanol
activates
Pseudomonas sp.
dithiothreitol
activates
Pseudomonas sp.
GSH
activates
Pseudomonas sp.
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
biguanide
-
Pseudomonas sp.
bisulfite
sodiumbisulfite
Pseudomonas sp.
bisulfite
-
Pseudomonas putida
CN-
KCN
Pseudomonas putida
CN-
KCN
Pseudomonas sp.
EDTA
-
Pseudomonas putida
EDTA
-
Pseudomonas sp.
hydroxylamine
-
Pseudomonas sp.
L-cysteine
-
Pseudomonas putida
L-cysteine
-
Pseudomonas sp.
L-tyrosine
heat-purified enzyme, at low concentrations, pH 7-8
Pseudomonas sp.
NaBH4
-
Pseudomonas sp.
p-hydroxyphenylpyruvate
heat-purified enzyme, at low concentrations, pH 7-8
Pseudomonas sp.
p-mercuribenzoate
inhibits mercaptoethanol-activated enzyme
Pseudomonas sp.
phenylhydrazine
-
Pseudomonas sp.
Sodium diphosphate
-
Pseudomonas sp.
Urocanate
-
Pseudomonas aeruginosa
Urocanate
heat-purified enzyme, at low concentrations, pH 7-8
Pseudomonas sp.
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.8
-
L-histidine
25°C
Pseudomonas sp.
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mn2+
enhances activity
Pseudomonas sp.
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
210000
-
-
Pseudomonas aeruginosa
210000
-
sedimentation equilibrium
Pseudomonas sp.
Purification (Commentary) (protein specific)
Commentary
Organism
-
Pseudomonas sp.
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Pseudomonas putida
additional information
-
-
Pseudomonas sp.
Storage Stability (protein specific)
Storage Stability
Organism
2°C, 0.1 M potassium phosphate, pH 7.2, 0.1 mM MnCl2 saturated with chloroform, stable for 9 months without loss of activity
Pseudomonas sp.
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-histidine
natural substrate
34278
Pseudomonas aeruginosa
urocanate + NH3
-
34278
Pseudomonas aeruginosa
?
L-histidine
natural substrate
34278
Pseudomonas sp.
urocanate + NH3
-
34278
Pseudomonas sp.
?
L-histidine
natural substrate
34278
Pseudomonas putida
urocanate + NH3
-
34278
Pseudomonas putida
-
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
-
Pseudomonas sp.
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
8.1
9.9
50% of maximal activity at pH 8.1 and pH 9.9
Pseudomonas sp.
Other publictions for EC 4.3.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
747346
Yamaguchi
Bidirectional reporter assay ...
Homo sapiens
Biotechnol. Bioeng.
114
2868-2882
2017
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1
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1
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1
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-
747652
Luu
Direct regulation of histidin ...
Xenopus laevis, Xenopus tropicalis
Endocrinology
158
1022-1033
2017
-
-
2
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-
-
-
-
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4
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4
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2
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2
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747109
Sanchez-Murcia
Stepwise simulation of 3,5-di ...
Pseudomonas putida
Biochemistry
55
5854-5864
2016
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2
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1
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1
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1
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729543
Luu
Differential regulation of two ...
Xenopus laevis, Xenopus tropicalis
Cell Biosci.
3
43
2013
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6
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8
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10
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2
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2
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715968
Seff
Computational investigation of ...
Pseudomonas putida
J. Mol. Model.
17
1551-1563
2011
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1
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3
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716438
Reilly
Inhibition of histidine ammoni ...
Pseudomonas putida
Photochem. Photobiol.
86
1272-1277
2010
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1
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1
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691650
Welsh
A role for ultraviolet radiati ...
Homo sapiens
Carcinogenesis
29
1950-1954
2008
2
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1
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2
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1
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1
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1
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693378
Eckhart
Histidase expression in human ...
Homo sapiens
J. Dermatol. Sci.
50
209-215
2008
1
-
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-
4
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1
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2
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4
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1
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1
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1
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4
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1
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4
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1
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1
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679156
Katona
Inhibition of histidine ammoni ...
Pseudomonas putida
Chem. Biodivers.
3
502-508
2006
-
-
1
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-
20
-
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1
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1
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1
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1
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1
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1
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20
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1
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20
20
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1
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1
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1
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1
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1
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665126
Kawai
Molecular characterization of ...
Homo sapiens
Hum. Genet.
116
340-346
2005
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2
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663816
Asano
-
Structure and Function of Amin ...
Pseudomonas putida
Biocatal. Biotransform.
22
131-138
2004
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1
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666649
Hellio
Amino acid utilization by Chla ...
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii CCAP 11/32A
Plant Physiol. Biochem.
42
257-264
2004
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1
5
1
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1
2
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4
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666902
Ortiz
Production of recombinant rat ...
Rattus norvegicus
Rev. Invest. Clin.
56
43-50
2004
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1
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653903
Baedeker
Autocatalytic peptide cyclizat ...
Pseudomonas putida
Structure
10
61-67
2002
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1
1
11
-
1
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1
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1
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1
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1
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11
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1
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651111
Rother
Characterization of the active ...
Pseudomonas putida
Eur. J. Biochem.
268
6011-6019
2001
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1
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11
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1
1
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3
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11
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651573
Donnelly
Computational analysis of the ...
Homo sapiens
J. Am. Chem. Soc.
123
4679-4686
2001
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651437
Merkel
-
Further insight into the mecha ...
Pseudomonas putida
Helv. Chim. Acta
83
1151-1160
2000
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1
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1
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1
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653093
Ascencio
Hepatic histidase and muscle b ...
Rattus norvegicus
Life Sci.
67
2775-2784
2000
-
-
-
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1
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2
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34309
Schwede
Homogenization and crystalliza ...
Pseudomonas putida
Protein Eng.
12
151-153
1999
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1
1
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1
1
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3
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1
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2
1
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1
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1
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1
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2
1
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34310
Schwede
Crystal structure of histidine ...
Pseudomonas putida
Biochemistry
38
5355-5361
1999
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1
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3
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1
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1
1
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651565
Galpin
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The Inactivation of Histidine ...
Pseudomonas putida
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1999
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34308
Sano
Isolation of a rat histidase c ...
Mus musculus, Rattus norvegicus
Eur. J. Biochem.
250
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1997
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34307
Weber
On the nature of the irreversi ...
Pseudomonas putida
Bioorg. Med. Chem.
4
1001-1006
1996
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34305
Hernandez
1-amino-2-imidazol-4 -ylethylp ...
Pseudomonas putida
Biochem. Mol. Biol. Int.
32
189-194
1994
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3
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34306
Hernandez
Ser-143 is an essential active ...
Pseudomonas putida
Biochem. Biophys. Res. Commun.
201
1433-1438
1994
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3
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34302
Hernandez
Purification and Characterizat ...
Pseudomonas putida, Pseudomonas putida PRS1, Pseudomonas sp.
Protein Expr. Purif.
4
473-478
1993
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1
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7
2
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4
2
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7
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2
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34303
White
Inactivation of histidine ammo ...
Streptomyces griseus
Biochim. Biophys. Acta
1163
273-279
1993
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5
1
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34304
Ahmed
-
Catabolite repression of histi ...
Bacillus subtilis, Klebsiella pneumoniae subsp. pneumoniae, Lysinibacillus sphaericus, Lysinibacillus sphaericus 2362
FEMS Microbiol. Lett.
106
71-75
1993
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6
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34301
Wu
Histidine ammonia-lyase from S ...
Streptomyces griseus, Streptomyces griseus NRRL B-2682
Gene
115
19-25
1992
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3
1
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8
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1
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34300
Burton
-
Inductive and repressive effec ...
unidentified
Soil Biol. Biochem.
23
939-946
1991
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34299
Khanna
Characterization of L-histidin ...
Pseudomonas fluorescens
Int. J. Artif. Organs
13
189-195
1990
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1
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1
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1
2
1
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34298
Kroening
Cascading regulation of histid ...
Streptomyces griseus
J. Bacteriol.
171
1100-1105
1989
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34297
Oda
Cloning and nucleotide sequenc ...
Bacillus subtilis, Bacillus subtilis Marburg 168
J. Bacteriol.
170
3199-3205
1988
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1
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1
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-
5766
Consevage
Cloning and expression in Esch ...
Pseudomonas putida
J. Bacteriol.
162
138-146
1985
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6
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1
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34296
Fuchs
In vivo synthesis of histidine ...
Klebsiella pneumoniae subsp. pneumoniae
J. Bacteriol.
162
98-101
1985
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2
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1
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34293
Allen
-
Histidine ammonia-lyase from k ...
Oncorhynchus mykiss, Scombridae
Biochem. Soc. Trans.
11
350
1983
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4
2
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2
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4
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1
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4
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3
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1
1
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34294
Allen
-
Histidine ammonia-lyase in gui ...
Cavia porcellus
Biochem. Soc. Trans.
11
349-350
1983
1
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3
3
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1
1
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1
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34292
Polkinghorne
L-Histidine utilization in Asp ...
Aspergillus nidulans
J. Bacteriol.
149
931-940
1982
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34291
Walters
-
Histidine ammonia-lyase enzyme ...
Pseudomonas sp.
Anal. Chem.
52
1684-1690
1980
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1
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1
1
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1
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34290
Kamel
-
Co-factor requirements and fac ...
Vicia faba
Z. Pflanzenphysiol.
88
255-262
1978
1
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1
1
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1
1
-
1
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-
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-
34288
Brand
Histidine ammonia-lyase from r ...
Pseudomonas fluorescens, Rattus norvegicus
Biochemistry
15
1814-1821
1976
-
-
-
-
-
-
14
4
-
-
1
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5
-
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1
2
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2
1
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4
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1
1
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14
-
4
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1
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1
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2
1
-
4
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1
1
-
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-
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-
-
-
-
34289
Brand L.M.; Harper
DL-alpha-Hydrazinoimidazolylpr ...
Rattus norvegicus
Arch. Biochem. Biophys.
177
123-132
1976
-
-
-
-
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5
-
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1
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1
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2
1
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1
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5
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1
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2
1
-
1
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-
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-
34286
Klee
Histidine ammonia-lyase. The u ...
Pseudomonas sp.
J. Biol. Chem.
250
5033-5040
1975
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-
-
-
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2
8
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1
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-
1
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-
1
-
4
-
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1
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2
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8
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1
-
4
-
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1
-
-
-
-
-
-
-
-
34287
Shibatani
Crystalline L-histidine ammoni ...
Achromobacter liquidum, Achromobacter liquidum IAM 1667, Bacillus cereus, Bacillus subtilis, Comamonas testosteroni, Helianthus sp., Mycobacterium avium, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas sp., Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Spinacia oleracea, Vibrio cholerae
Eur. J. Biochem.
55
263-269
1975
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1
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29
1
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-
2
-
-
16
-
-
1
-
1
-
1
2
15
-
1
-
1
-
3
1
-
-
-
-
-
-
-
-
-
1
-
-
-
29
-
1
-
-
2
-
-
-
-
1
1
-
1
2
15
-
1
-
1
-
3
1
-
-
-
-
-
-
-
-
34283
Hug
Effect of temperature on histi ...
Pseudomonas putida, Pseudomonas putida A.3.12, Rattus norvegicus
J. Bacteriol.
119
92-97
1974
-
-
-
-
-
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-
2
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6
-
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2
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5
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2
3
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2
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-
2
-
5
-
2
3
-
-
-
-
-
-
-
-
-
-
-
-
34284
Okamura
L-histidine ammonia-lyase in r ...
Cavia porcellus, Rattus norvegicus
J. Biochem.
75
139-152
1974
3
-
-
-
-
-
9
1
-
7
1
-
-
2
-
-
1
-
-
2
3
3
2
-
-
-
-
-
1
1
-
-
-
-
-
3
-
-
-
-
-
-
-
9
-
1
-
7
1
-
-
-
-
1
-
2
3
3
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
34285
Klee
Stereospecific irreversible in ...
Pseudomonas sp.
Biochemistry
13
4501-4507
1974
-
-
-
-
-
-
4
-
-
-
-
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-
1
2
-
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-
1
-
1
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-
1
-
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-
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-
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4
-
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-
2
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-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5997
Hanson
-
The enzymic elimination of amm ...
Bacillus subtilis, Comamonas testosteroni, Homo sapiens, Klebsiella aerogenes, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas fluorescens A.3.12, Pseudomonas sp., Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, toad
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
7
75-166
1972
-
-
-
-
-
-
-
3
-
-
10
4
-
11
-
-
-
10
-
3
5
-
15
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
3
-
-
10
4
-
-
-
-
-
3
5
-
15
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34276
Klee
Metal activation of histidine ...
Pseudomonas sp.
J. Biol. Chem.
247
1398-1406
1972
-
-
-
-
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3
3
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5
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1
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-
8
-
1
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3
-
3
-
5
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8
-
1
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34282
Morris
Influence of differential indu ...
Rattus norvegicus
J. Biol. Chem.
247
5793-5804
1972
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34277
Klee
-
Histidine ammonia-lyase (Pseud ...
Pseudomonas sp.
Methods Enzymol.
17B
69-73
1971
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34278
Rechler
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Histidine ammonia-lyase (Pseud ...
Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas sp.
Methods Enzymol.
17B
63-69
1971
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34279
Magasanik
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Histidase (histidine ammonia-l ...
Bacillus subtilis, Bacillus subtilis W23G, Klebsiella aerogenes, Salmonella enterica subsp. enterica serovar Typhimurium
Methods Enzymol.
17B
47-50
1971
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34280
Hassall
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Use of L-histidine ammonia-lya ...
Homo sapiens, Pseudomonas putida, Pseudomonas sp.
Methods Enzymol.
17B
895-897
1971
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34281
La Du
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L-Histidine ammonia-lyase (hum ...
Homo sapiens
Methods Enzymol.
17B
891-894
1971
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34274
Mehler
Deamination of histidine to fo ...
Cavia porcellus, Pseudomonas fluorescens
J. Biol. Chem.
201
775-784
1953
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