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Literature summary for 4.3.1.24 extracted from
- Kinetic analysis of the inhibition of phenylalanine ammonia-lyase by 2-aminoindan-2-phosphonic acid and other phenylalanine analogues (2003), Phytochemistry, 62, 415-422.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Petroselinum crispum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (+-)-2-aminomethyl-3-phenylpropanoic acid | - |
Petroselinum crispum |  |
| (R)-1-amino-2-(4-fluorophenyl)ethylphosphonic acid | - |
Petroselinum crispum | |
| (S)-2-aminooxy-3-phenylpropanoic acid | very strong inhibition | Petroselinum crispum | |
| 2-aminoindan-2-carboxylic acid | - |
Petroselinum crispum | |
| 2-aminoindan-2-phosphonic acid | - |
Petroselinum crispum | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine | Petroselinum crispum | - |
(E)-cinnamate + NH3 | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Petroselinum crispum | - |
parsley | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant PAL | Petroselinum crispum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine | - |
Petroselinum crispum | (E)-cinnamate + NH3 | - |
? | |
| L-phenylalanine | - |
Petroselinum crispum | (E)-cinnamate + NH3 | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAL | - |
Petroselinum crispum |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00000038 | - |
(S)-2-aminooxy-3-phenylpropanoic acid | 40°C, pH 8.8 | Petroselinum crispum | |
| 0.000025 | - |
2-aminoindan-2-phosphonic acid | 40°C, pH 8.8 | Petroselinum crispum | |
| 0.001 | - |
(R)-1-amino-2-(4-fluorophenyl)ethylphosphonic acid | 40°C, pH 8.8 | Petroselinum crispum | |
| 0.0019 | - |
2-aminoindan-2-carboxylic acid | 40°C, pH 8.8 | Petroselinum crispum | |
| 0.0089 | - |
(+-)-2-aminomethyl-3-phenylpropanoic acid | 40°C, pH 8.8 | Petroselinum crispum | |
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