Literature summary for 4.3.1.19 extracted from

Guillouet, S.; Rodal, A.A.; An, G.H.; Lessard, P.A.; Sinskey, A.J.
Expression of the Escherichia coli catabolic threonine dehydratase in Corynebacterium glutamicum and its effect on isoleucine production (1999), Appl. Environ. Microbiol., 65, 3100-3107.

Search for more literature for 4.3.1.19

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Brevibacterium flavum	Escherichia coli
expression in Corynebacterium glutamicum	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
Ile	native enzyme is totally inhibited by 15 mM Ile, the heterologous catabolic enzyme from E. coli retains 60% of its original activity even in presence of 200 mM Ile	Corynebacterium glutamicum
Ile	biodegradative enzyme is feedback-resistant	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-Thr	Escherichia coli	first reaction of the Ile pathway	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	-	-	-
Escherichia coli	-	biodegradative threonine dehydratase	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Thr	first reaction of the Ile pathway	Escherichia coli	?	-	?
L-threonine	-	Escherichia coli	2-oxobutanoate + NH3	-	?
L-threonine	-	Corynebacterium glutamicum	2-oxobutanoate + NH3	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)