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Literature summary for 4.3.1.18 extracted from

  • Ito, T.; Takada, H.; Isobe, K.; Suzuki, M.; Kitaura, Y.; Hemmi, H.; Matsuda, T.; Sasabe, J.; Yoshimura, T.
    PEGylated D-serine dehydratase as a D-serine reducing agent (2015), J. Pharm. Biomed. Anal., 116, 34-39 .
    View publication on PubMed
Search for more literature for 4.3.1.18

Application

Application Comment Organism
pharmacology decrease in D-serine content may provide a therapeutic strategy for the treatment of the neurological disorders in which overstimulation of N-methyl-D-aspartate receptors plays a pathological role. D-Serine dehydratase (Dsd1p), which acts dominantly on D-serine, may be a useful D-serine reducing agent. A linear 5-kDa polyethylene glycol (PEG) is conjugated to Dsd1p and the effects of PEG-conjugation on its biochemical and pharmacokinetic properties are examined. PEG-Dsd1p retains activity, specificity, and stability of the enzyme. The PEG modification extended the serum half-life of Dsd1p in mice 6fold, from 3.8 h to 22.4 h. PEG-Dsd1p is much less immunogenic compared to the unmodified enzyme. Intraperitoneal administration of PEG-Dsd1p is effective in decreasing the D-serine content in the mouse hippocampus Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P53095 the strain is derioved from strain S288c
-
Saccharomyces cerevisiae BY4742 P53095 the strain is derioved from strain S288c
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine
-
 Saccharomyces cerevisiae pyruvate + NH3
-
 ?
D-serine
-
 Saccharomyces cerevisiae BY4742 pyruvate + NH3
-
 ?

Synonyms

Synonyms Comment Organism
Dsd1p
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Saccharomyces cerevisiae