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Literature summary for 4.3.1.18 extracted from
- D-Serine metabolism and its importance in development of Dictyostelium discoideum (2018), Front. Microbiol., 9, 784 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.19 | - |
D-serine | pH 8.5, 30°C | Dictyostelium discoideum |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-serine | Dictyostelium discoideum | the enzyme is 460fold and 1700fold more active than D-amino acid oxidase and serine racemase, respectively, in degrading D-Ser | pyruvate + NH3 | - |
? | |
| D-serine | Dictyostelium discoideum AX2 | the enzyme is 460fold and 1700fold more active than D-amino acid oxidase and serine racemase, respectively, in degrading D-Ser | pyruvate + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dictyostelium discoideum | Q54HH2 | - |
- |
| Dictyostelium discoideum AX2 | Q54HH2 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Dictyostelium discoideum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-serine | - |
Dictyostelium discoideum | pyruvate + NH3 | - |
? | |
| D-serine | the enzyme is 460fold and 1700fold more active than D-amino acid oxidase and serine racemase, respectively, in degrading D-Ser | Dictyostelium discoideum | pyruvate + NH3 | - |
? | |
| D-serine | - |
Dictyostelium discoideum AX2 | pyruvate + NH3 | - |
? | |
| D-serine | the enzyme is 460fold and 1700fold more active than D-amino acid oxidase and serine racemase, respectively, in degrading D-Ser | Dictyostelium discoideum AX2 | pyruvate + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-Ser dehydratase | - |
Dictyostelium discoideum |
| DDB_G0289463 | - |
Dictyostelium discoideum |
| DSD | - |
Dictyostelium discoideum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Dictyostelium discoideum |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.6 | - |
D-serine | pH 8.5, 30°C | Dictyostelium discoideum | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Dictyostelium discoideum |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | dsd-null cells exhibit delay in development and arrest at the early culmination stage. The efficiency of spore formation is considerably reduced in the mutant cells | Dictyostelium discoideum |
| metabolism | the enzyme is 460fold and 1700fold more active than D-amino acid oxidase and serine racemase, respectively, in degrading D-Ser. D-Ser dehydrogenase is the primary enzyme responsible for D-Ser decomposition in Dictyostelium discoideum | Dictyostelium discoideum |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 14 | - |
D-serine | pH 8.5, 30°C | Dictyostelium discoideum | |
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