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Literature summary for 4.3.1.17 extracted from

  • Lopez-Flores, I.; Barroso, J.B.; Valderrama, R.; Esteban, F.J.; Martinez-Lara, E.; Luque, F.; Peinado, M.A.; Ogawa, H.; Lupianez, J.A.; Peragon, J.
    Serine dehydratase expression decreases in rat livers injured by chronic thioacetamide ingestion (2005), Mol. Cell. Biochem., 268, 33-43.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
177
-
L-serine pH 7.4, 25°C Rattus norvegicus
182
-
L-serine pH 7.4, 25°C, animals treated with thioacetamide for 97 days Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
treated by oral intake of thioacetamide
-

Source Tissue

Source Tissue Comment Organism Textmining
liver suffering chronic injury caused by ingestion of thioacetamide. After 97 days of intake, enzyme activity is about 60% lower than in controls. No significant differences in Km-value are found, while enzyme protein level is reduced. Enzyme is localized to periportal zone of the hepatic acinus Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
Rattus norvegicus pyruvate + NH3
-
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