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Literature summary for 4.3.1.17 extracted from

  • Hoshino, J.; Simon, D.; Kroeger, H.
    Influence of monovalent cations on the activity of L-serine (L-threonine) dehydratase from rat liver (1972), Eur. J. Biochem., 27, 388-394.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
PCMB NH4+ protects Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
75
-
L-Ser in presence of 20 mM NH4Cl Rattus norvegicus
100
-
L-Ser without NH4+ Rattus norvegicus
130
-
L-Thr in presence and in absence of 20 mM NH4Cl Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ slight stimulation Rattus norvegicus
NH4+ slight stimulation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
Rattus norvegicus pyruvate + NH3
-
?
L-Thr
-
Rattus norvegicus 2-oxobutanoate + NH3
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
55
-
complete loss of activity after 4 min. NH4Cl, KCl or (NH4)2SO4 stabilize Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate coenzyme Rattus norvegicus