Literature summary for 4.3.1.1 extracted from

Xu, J.; Zhang, J.; Guo, Y.; Zhang, W.
Genetically modifying aspartate aminotransferase and aspartate ammonia-lyase affects metabolite accumulation in L-lysine producing strain derived from Corynebacterium glutamicum ATCC13032 (2015), J. Mol. Catal. B, 113, 82-89 .

No PubMed abstract available

Cloned(Commentary)

Cloned (Comment)	Organism
although Corynebacterium glutamicum posses the aspartate ammonia-lyase gene (aspA), aspartate aminotransferase (AAT) is necessary to cell growth and L-lysine production, because the activity of Corynebacterium glutamicum aspartate ammonia-lyase (AAL) is too low to maintain the cell growth. Escherichia coli aspartate ammonia-lyase helps to restore the cell growth of aspB-deleted strain and also leads to the accumulation of L-lysine, L-glutamate, pyruvate and 2-oxoglutarate	Escherichia coli

Cloned (Comment)

Organism

although Corynebacterium glutamicum posses the aspartate ammonia-lyase gene (aspA), aspartate aminotransferase (AAT) is necessary to cell growth and L-lysine production, because the activity of Corynebacterium glutamicum aspartate ammonia-lyase (AAL) is too low to maintain the cell growth. Escherichia coli aspartate ammonia-lyase helps to restore the cell growth of aspB-deleted strain and also leads to the accumulation of L-lysine, L-glutamate, pyruvate and 2-oxoglutarate

Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
52000	-	SDS-PAGE	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
fumarate + NH3	Escherichia coli	important enzyme in production of L-aspartate	L-aspartate	-	r
fumarate + NH3	Escherichia coli MG1655	important enzyme in production of L-aspartate	L-aspartate	-	r

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0AC38	-	-
Escherichia coli MG1655	P0AC38	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
fumarate + NH3	-	Escherichia coli	L-aspartate	-	r
fumarate + NH3	important enzyme in production of L-aspartate	Escherichia coli	L-aspartate	-	r
fumarate + NH3	-	Escherichia coli MG1655	L-aspartate	-	r
fumarate + NH3	important enzyme in production of L-aspartate	Escherichia coli MG1655	L-aspartate	-	r
L-aspartate	-	Escherichia coli	fumarate + NH3	-	r
L-aspartate	-	Escherichia coli MG1655	fumarate + NH3	-	r

Subunits

Subunits	Comment	Organism
?	x * 52000, SDS-PAGE	Escherichia coli

Synonyms

Synonyms	Comment	Organism
ASPA	-	Escherichia coli

General Information

General Information	Comment	Organism
metabolism	important enzyme in production of L-aspartate	Escherichia coli