Literature summary for 4.2.99.B1 extracted from

Roberts, S.A.; Strande, N.; Burkhalter, M.D.; Strom, C.; Havener, J.M.; Hasty, P.; Ramsden, D.A.
Ku is a 5-dRP/AP lyase that excises nucleotide damage near broken ends (2010), Nature, 464, 1214-1217.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
Ku70	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	accurate and efficient repair by nonhomologous end joining NHEJ of double-strand breaks with such damage similarly requires 5'-deoxyribose phosphate/abasic lyase activity provided by Ku70. Ku70 nicks DNA 3' of an abasic site by a mechanism involving a Schiff base covalent intermediate with the abasic site. Ku70 is essential for efficient removal of abasic sites near double strand breaks and, consistent with this result, joining of such breaks is specifically reduced in cells complemented with a lyase-attenuated Ku mutant	Mus musculus

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Release 2023.1 (January 2023)