Literature summary for 4.2.99.B1 extracted from

Allinson, S.L.; Dianova, II; Dianov, G.L.
DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts (2001), EMBO J., 20, 6919-6926.

Search for more literature for 4.2.99.B1

Protein Variants

Protein Variants	Comment	Organism
K72A	mutant is not able to exhibit short-patch repair mechanism	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site	DNA polymerase beta as the major polymerase involved in repair of oxidative base lesions, in single nucleotide replacement mechanisms. The 5'-deoxyribosephosphate lyase activity of Pol beta is essential for repair	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
closed-circular double-stranded DNA substrate bearing a single 8-oxoguanine/cytosine base pair at a defined position	-	Homo sapiens	? + 2-deoxy-D-ribose 5-phosphate	-	?
closed-circular double-stranded DNA substrate bearing a single dihydrouracil/guanine base pair at a defined position	-	Homo sapiens	? + 2-deoxy-D-ribose 5-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
5'-deoxyribosephosphate lyase	-	Homo sapiens
DNA polymerase beta	exhibits dRP lyase activity	Homo sapiens
pol beta	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)