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Literature summary for 4.2.99.21 extracted from

  • Manos-Turvey, A.; Bulloch, E.M.M.; Rutledge, P.J.; Baker, E.N.; Lott, J.S.; Payne, R.J.
    Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI) (2010), ChemMedChem, 5, 1067-1079.
    View publication on PubMed
Search for more literature for 4.2.99.21

Crystallization (Commentary)

Crystallization (Comment) Organism
docking studies of inhibitors (E)-3-(1-carboxyprop-1-enyloxy)-2-hydroxybenzoic acid, 3-(1-carboxy-3-methylbut-1-enyloxy)-2-hydroxybenzoic acid, 3-(1-carboxybut-1-enyloxy)-2-hydroxybenzoic acid, and 3-(1-carboxy-2-phenylvinyloxy)-2-hydroxybenzoic acid Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
(E)-3-(1-carboxyprop-1-enyloxy)-2-hydroxybenzoic acid low micromolar inhibition of both isochorismate lyase and anthranilate synthase Mycobacterium tuberculosis
3-(1-carboxy-2-phenylvinyloxy)-2-hydroxybenzoic acid low micromolar inhibition of both isochorismate lyase and anthranilate synthase Mycobacterium tuberculosis
3-(1-carboxy-3-methylbut-1-enyloxy)-2-hydroxybenzoic acid low micromolar inhibition of both isochorismate lyase and anthranilate synthase Mycobacterium tuberculosis
3-(1-carboxybut-1-enyloxy)-2-hydroxybenzoic acid low micromolar inhibition of both isochorismate lyase and anthranilate synthase Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0021
-
 isochorismate pH 8.0, 25°C Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isochorismate
-
 Mycobacterium tuberculosis salicylate + pyruvate
-
 ?

Synonyms

Synonyms Comment Organism
salicylate synthase
-
 Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.8
-
 isochorismate pH 8.0, 25°C Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.012
-
 3-(1-carboxybut-1-enyloxy)-2-hydroxybenzoic acid pH 8.0, 25°C Mycobacterium tuberculosis
0.013
-
 (E)-3-(1-carboxyprop-1-enyloxy)-2-hydroxybenzoic acid pH 8.0, 25°C Mycobacterium tuberculosis
0.014
-
 3-(1-carboxy-3-methylbut-1-enyloxy)-2-hydroxybenzoic acid pH 8.0, 25°C Mycobacterium tuberculosis
0.021
-
 3-(1-carboxy-2-phenylvinyloxy)-2-hydroxybenzoic acid pH 8.0, 25°C Mycobacterium tuberculosis