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Literature summary for 4.2.99.18 extracted from

  • Jiang, X.; Shan, J.; Dai, N.; Zhong, Z.; Qing, Y.; Yang, Y.; Zhang, S.; Li, C.; Sui, J.; Ren, T.; Li, M.; Wang, D.
    Apurinic/apyrimidinic endonuclease 1 regulates angiogenesis in a transforming growth factor beta-dependent manner in human osteosarcoma (2015), Cancer Sci., 106, 1394-1401 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information apurinic/apyrimidinic endonuclease 1-siRNA-mediated downregulation in osteosarcoma cells inhibits expression of TGFbeta1. Apurinic/apyrimidinic endonuclease 1-siRNA inhibits the capability to enhance HUVEC migration and tube formation of tumor cells through the TGFbeta/Smad3 signaling pathway. Tumor angiogenesis and growth in xenografts are suppressed by APE1-siRNA Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27695
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteosarcoma cell osteosarcoma 9901 cell Homo sapiens
-

Synonyms

Synonyms Comment Organism
APE1
-
 Homo sapiens
apurinic/apyrimidinic endonuclease 1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the expression of transforming growth factor beta (TGFbeta) is significantly reduced in APE1-deficient osteosarcoma cells. Transforming growth factor beta promotes cancer metastasis through various mechanisms including immunosuppression, angiogenesis, and invasion. APE1, TGFbeta, and microvessel density (MVD) have a pairwise correlation in osteosarcoma tissue samples, whereas TGFbeta, tumor size, and MVD are inversely related to the prognosis of the cohort. High expression of APE1, TGFbeta, and microvessel density (MVD) correlate with poor prognosis of osteosarcoma patients. Apurinic/apyrimidinic endonuclease 1-siRNA-mediated downregulation in osteosarcoma cells inhibits expression of TGFbeta1. Apurinic/apyrimidinic endonuclease 1-siRNA inhibits the capability to enhance HUVEC migration and tube formation of tumor cells through the TGFbeta/Smad3 signaling pathway. Tumor angiogenesis and growth in xenografts are suppressed by APE1-siRNA Homo sapiens
physiological function apurinic/apyrimidinic endonuclease 1 is a multifunctional protein playing crucial roles in DNA base excision repair and redox regulation of gene expression, activities that are functionally and structurally independent of each other. The APE1 redox activity stimulates numerous transcriptional factors, including activator protein-1 (AP-1), nuclear factor-kappaB (NF-happaB), and HIF-1. These factors are involved in mediating VEGF gene expression; HIF-1 and NF-kappaB, in particular, increased VEGF expression in response to hypoxia. Apurinic/apyrimidinic endonuclease 1 (APE1) is a dually functional protein possessing both base excision repair and redox activities, it is involved in tumor angiogenesis. APE1, TGFbeta, and microvessel density (MVD) have a pairwise correlation in osteosarcoma tissue samples, whereas TGFbeta, tumor size, and MVD are inversely related to the prognosis of the cohort. High expression of APE1, TGFbeta, and microvessel density (MVD) correlate with poor prognosis of osteosarcoma patients. APE1 may indirectly regulate angiogenesis through a TGFbeta-dependent pathway Homo sapiens