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Literature summary for 4.2.99.18 extracted from
- Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) (2017), Bioorg. Med. Chem., 25, 2531-2544 .
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | APE1/Ref-1 expression levels together with subcellular dysregulation may be predictive markers to indicate the tumor sensitivity toward radiotherapy or chemotherapy | Homo sapiens |
| pharmacology | the enzyme is a potential target in cancer treatment | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione | - |
Homo sapiens |  |
| (2E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile | - |
Homo sapiens | |
| (2E)-2-methyl-3-[3-(methylsulfanyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]prop-2-enoic acid | - |
Homo sapiens | |
| (2E)-2-[(3-bromo-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-4-methoxybutanoic acid | - |
Homo sapiens | |
| (2E)-2-[(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-4-methoxybutanoic acid | - |
Homo sapiens | |
| (2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]-N-methoxydodecanamide | i.e. E3330-amide | Homo sapiens | |
| (2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]dodecanoic acid | i.e. E3330 | Homo sapiens | |
| (2E)-3-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-methylprop-2-enoic acid | - |
Homo sapiens | |
| (2E)-3-(2-chloro-4,5-dimethoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-2-methylprop-2-enoic acid | - |
Homo sapiens | |
| (2E)-3-(3-bromo-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-methylprop-2-enoic acid | - |
Homo sapiens | |
| (2E)-3-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-methylprop-2-enoic acid | - |
Homo sapiens | |
| (2E)-3-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(2-hydroxyethyl)-2-methylprop-2-enamide | - |
Homo sapiens | |
| (2E)-3-(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-methylprop-2-enoic acid | - |
Homo sapiens | |
| (2E)-3-[3-[dihydroxy(oxido)-lambda5-stibanyl]phenyl]prop-2-enoic acid | - |
Homo sapiens | |
| (2R)-1-(1-benzofuran-2-yl)-2-(1,3-benzothiazol-2-yl)-2-hydroxyethanone | - |
Homo sapiens | |
| (3-chloro-1-benzothiophen-2-yl)[(2Z)-2-[(2-chlorophenyl)imino]-4-methylidene-3-thia-1-azaspiro[4.5]dec-1-yl]methanone | - |
Homo sapiens | |
| (3a'S,6a'R)-5'-(1,3-benzodioxol-5-ylmethyl)-3'-(2-carboxyethyl)-7-chloro-2,4',6'-trioxo-1,2,3',3a',4',5',6',6a'-octahydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrol[2]ium] | - |
Homo sapiens | |
| (5E)-1-(furan-2-ylmethyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]pyrimidine-2,4,6(1H,3H,5H)-trione | - |
Homo sapiens | |
| (5R)-4-hydroxy-3,5-dimethyl-5-((2S)-3-methylpent-4-en-2-yl)thiophen-2(5H)-one | - |
Homo sapiens | |
| 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8,8'-dicarbaldehyde | - |
Homo sapiens | |
| 1,3-bis(1,3-benzothiazol-2-ylsulfanyl)propan-2-one | - |
Homo sapiens | |
| 1,4-dihydroxy-5,8-bis([2-[(2-hydroxyethyl)amino]ethyl]amino)anthracene-9,10-dione | - |
Homo sapiens | |
| 1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione | - |
Homo sapiens | |
| 1-amino-4-[[4-([4-chloro-6-[(4-sulfophenyl)amino]-1,3,5-triazin-2-yl]amino)phenyl]amino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid | - |
Homo sapiens | |
| 1-methyl-4-[(1E)-1-[2-(6-methyl[1,3]dioxolo[4,5-g]quinolin-8-yl)hydrazinylidene]ethyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one | - |
Homo sapiens | |
| 1-[3-[(6-chloro-2-methoxyacridin-9-yl)amino]propyl]-3-[3-(2,6-diamino-9H-purin-9-yl)propyl]guanidine | - |
Homo sapiens | |
| 1-[4-[(6-chloro-2-methoxyacridin-9-yl)amino]butyl]-3-[4-(2,6-diamino-9H-purin-9-yl)butyl]guanidine | - |
Homo sapiens | |
| 1-[[2-(ethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one | - |
Homo sapiens | |
| 1-[[2-(ethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one | - |
Homo sapiens | |
| 10,12-dimethyl-2-(propan-2-yl)-6H-[1,3]oxazolo[4,5-g]pyrido[4,3-b]carbazol-10-ium | - |
Homo sapiens | |
| 2,2'-[butane-1,4-diylbis(1H-benzimidazole-2,1-diyl)]diacetic acid | - |
Homo sapiens | |
| 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine | - |
Homo sapiens | |
| 2,4-di-tert-butylphenyl 3-chloro-1-benzothiophene-2-carboxylate | - |
Homo sapiens | |
| 2,5-dihydroxy-DL-tyrosine | - |
Homo sapiens | |
| 2,7-BisNP-NH | - |
Homo sapiens | |
| 2,7-BisNP-O | - |
Homo sapiens | |
| 2-(2,4-dichlorophenyl)-6-nitro-4H-3,1-benzoxazin-4-one | - |
Homo sapiens | |
| 2-(4-chlorophenyl)-4-(2'-fluorobiphenyl-4-yl)-5-methyl-1,3-thiazole | - |
Homo sapiens | |
| 2-(carboxymethyl)-4-([4-[(4-carboxyphenyl)sulfanyl]phenyl]sulfonyl)benzoic acid | - |
Homo sapiens | |
| 2-amino-3-(3-[2-amino-1-[2-(6-amino-9H-purin-9-yl)ethyl]triaz-2-en-2-ium-1-yl]propyl)-3-[3-[(6-chloro-2-methoxyacridin-9-yl)amino]propyl]triaz-1-en-2-ium | - |
Homo sapiens | |
| 2-aminobenzene-1,3,5-trisulfonamide | - |
Homo sapiens | |
| 2-methoxy-3-[(3-methoxybenzyl)carbamoyl]benzoic acid | - |
Homo sapiens | |
| 2-[(5R)-3-(naphthalen-2-yl)-5-phenyl-2,5-dihydro-1H-pyrazol-1-yl]-2-oxoethyl 5-nitrothiophene-2-carboxylate | - |
Homo sapiens | |
| 2-[(Z)-(4-hydroxy-3-methylphenyl)(3-methyl-4-methylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzoic acid | - |
Homo sapiens | |
| 2-[5-[1-(carboxymethyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid | - |
Homo sapiens | |
| 3,3',4,4',5,5'-hexabromobiphenyl | - |
Homo sapiens | |
| 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid) | - |
Homo sapiens | |
| 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
| 3,6,7-trimethoxyphenanthrene-2,5-diol | - |
Homo sapiens | |
| 3,8,9,10-tetrahydroxypyrano[3,2-c]isochromene-2,6-dione | - |
Homo sapiens | |
| 3-[(3,4-dichlorobenzyl)carbamoyl]-2-methoxybenzoic acid | - |
Homo sapiens | |
| 3-[(3,4-dimethoxybenzyl)carbamoyl]-2-methoxybenzoic acid | - |
Homo sapiens | |
| 3-[(3-chlorobenzyl)carbamoyl]-2-methoxybenzoic acid | - |
Homo sapiens | |
| 3-[1-(carboxymethyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]propanoic acid | - |
Homo sapiens | |
| 3-[4-[(3aR,9bR)-9-methoxy-1,3a,4,9b-tetrahydrochromeno[3,4-c]pyrrol-2(3H)-yl]butyl]-8-phenylpyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione | - |
Homo sapiens | |
| 4'-(2-chloro-6-nitrophenoxy)biphenyl-4-yl 4-tert-butylbenzenesulfonate | - |
Homo sapiens | |
| 4-benzyl-1-(3-[[(3-nitrophenyl)sulfonyl]amino]quinoxalin-2-yl)pyridinium | - |
Homo sapiens | |
| 4-[(4Z)-4-([5-[4-chloro-3-(ethoxycarbonyl)phenyl]furan-2-yl]methylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid | - |
Homo sapiens | |
| 4-[dihydroxy(oxido)-lamba5-stibanyl]-2-nitrobenzoic acid | - |
Homo sapiens | |
| 4-[methyl(nitroso)amino]benzene-1,2-diol | - |
Homo sapiens | |
| 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-amine | - |
Homo sapiens | |
| 5,5'-[ethane-1,2-diylbis(sulfanediylmethanediyl)]bis(2-methylfuran-3-carboxylic acid) | - |
Homo sapiens | |
| 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
| 5-(acetylamino)-2-[(E)-2-(4-isothiocyanato-3-sulfophenyl)ethenyl]benzenesulfonic acid (non-preferred name) | - |
Homo sapiens | |
| 5-(hydroxymethyl)furan-2-carbaldehyde | - |
Homo sapiens | |
| 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol | - |
Homo sapiens | |
| 5-[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl]-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
| 6-amino-4-hydroxy-5-[(E)-(4-nitro-2-sulfophenyl)diazenyl]naphthalene-2-sulfonic acid | - |
Homo sapiens | |
| 6-amino-5-[(E)-(4-amino-2-sulfophenyl)diazenyl]-4-hydroxynaphthalene-2-sulfonic acid | - |
Homo sapiens | |
| 7-chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one | - |
Homo sapiens | |
| 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
| 7-nitro-1H-indole-2-carboxylic acid | - |
Homo sapiens | |
| 8-[(2E)-2-(1,3-benzodioxol-5-ylmethylidene)hydrazinyl]-6-methyl[1,3]dioxolo[4,5-g]quinoline | - |
Homo sapiens | |
| 8-[(2E)-2-[(9-ethyl-9H-carbazol-3-yl)methylidene]hydrazinyl]-6-methyl[1,3]dioxolo[4,5-g]quinoline | - |
Homo sapiens | |
| 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one | - |
Homo sapiens | |
| biphenyl-4,4'-diyl bis(3,4-dichlorobenzenesulfonate) | - |
Homo sapiens | |
| ethyl 4-[4-[dihydroxy(oxido)-lambda5-stibanyl]phenyl]butanoate | - |
Homo sapiens | |
| methoxyamine | methoxyamine (CH3ONH2) specifically inhibits virtually all AP endonucleases, irrespective of their action modes | Homo sapiens | |
| additional information | identification of small molecule inhibitors against APE1/Ref-1 activities, structures and activities of APE1/Ref-1 inhibitors, that target both DNA repair and redox activities, molecular docking, overview | Homo sapiens | |
| N-(3,5-dichlorophenyl)-4-(2'-fluorobiphenyl-4-yl)-5-methyl-1,3-thiazol-2-amine | - |
Homo sapiens | |
| N-(3-chlorophenyl)-5,6-dihydro-4H-cyclopenta[d][1,2]oxazole-3-carboxamide | - |
Homo sapiens | |
| N-(9,10-dioxo-9,10-dihydroanthracen-1-yl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide | - |
Homo sapiens | |
| N-benzyl-2-(3-cyanophenyl)-1,3,7-trioxo-2,3,7,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazine-5-carboxamide | - |
Homo sapiens | |
| N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide | - |
Homo sapiens | |
| N-[3-(1,3-benzothiazol-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl]acetamide | - |
Homo sapiens | |
| N-[3-(1,3-benzothiazol-2-yl)-6-(propan-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide | - |
Homo sapiens | |
| N-[3-(4-phenyl-1,3-thiazol-2-yl)-6-(propan-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide | - |
Homo sapiens | |
| N-[4-[dihydroxy(oxido)-lambda5-stibanyl]phenyl]benzamide | - |
Homo sapiens | |
| tetrahydrofuran-2-ylmethyl 6-(furan-2-yl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate | - |
Homo sapiens | |
| [4-(2,5-dimethyl-1H-pyrrol-1-yl)phenoxy]acetic acid | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27695 | - |
- |
| Homo sapiens | Q9UBZ4 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | the transcript for APE2 is overall expressed | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| APE1 | - |
Homo sapiens |
| Ape2 | - |
Homo sapiens |
| apurinic/apyrimidinic endonuclease 1 | - |
Homo sapiens |
| apurinic/apyrimidinic endonuclease 2 | - |
Homo sapiens |
| redox effector factor 1 | - |
Homo sapiens |
| Ref-1 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000004 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[dihydroxy(oxido)-lamba5-stibanyl]-2-nitrobenzoic acid | |
| 0.000017 | - |
pH and temperature not specified in the publication | Homo sapiens | ethyl 4-[4-[dihydroxy(oxido)-lambda5-stibanyl]phenyl]butanoate | |
| 0.000055 | - |
pH and temperature not specified in the publication | Homo sapiens | 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid) | |
| 0.00008 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[[2-(ethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one | |
| 0.00011 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,5-dihydroxy-DL-tyrosine | |
| 0.0002 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-[3-[dihydroxy(oxido)-lambda5-stibanyl]phenyl]prop-2-enoic acid | |
| 0.0002 | - |
pH and temperature not specified in the publication | Homo sapiens | 3,3',4,4',5,5'-hexabromobiphenyl | |
| 0.00025 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-amino-4-[[4-([4-chloro-6-[(4-sulfophenyl)amino]-1,3,5-triazin-2-yl]amino)phenyl]amino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid | |
| 0.00025 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-(acetylamino)-2-[(E)-2-(4-isothiocyanato-3-sulfophenyl)ethenyl]benzenesulfonic acid (non-preferred name) | |
| 0.00028 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile | |
| 0.0003 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[dihydroxy(oxido)-lambda5-stibanyl]phenyl]benzamide | |
| 0.00032 | - |
pH and temperature not specified in the publication | Homo sapiens | 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one | |
| 0.0004 | - |
pH and temperature not specified in the publication | Homo sapiens | 3,6,7-trimethoxyphenanthrene-2,5-diol | |
| 0.0004 | - |
pH and temperature not specified in the publication | Homo sapiens | 3,8,9,10-tetrahydroxypyrano[3,2-c]isochromene-2,6-dione | |
| 0.0005 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[methyl(nitroso)amino]benzene-1,2-diol | |
| 0.0008 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,4-di-tert-butylphenyl 3-chloro-1-benzothiophene-2-carboxylate | |
| 0.0009 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(3,5-dichlorophenyl)-4-(2'-fluorobiphenyl-4-yl)-5-methyl-1,3-thiazol-2-amine | |
| 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-2-methyl-3-[3-(methylsulfanyl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]prop-2-enoic acid | |
| 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-2-[(3-bromo-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-4-methoxybutanoic acid | |
| 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-methylprop-2-enoic acid | |
| 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(2-hydroxyethyl)-2-methylprop-2-enamide | |
| 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-methylprop-2-enoic acid | |
| 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | (5R)-4-hydroxy-3,5-dimethyl-5-((2S)-3-methylpent-4-en-2-yl)thiophen-2(5H)-one | |
| 0.0013 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(4-chlorophenyl)-4-(2'-fluorobiphenyl-4-yl)-5-methyl-1,3-thiazole | |
| 0.0014 | - |
pH and temperature not specified in the publication | Homo sapiens | (3-chloro-1-benzothiophen-2-yl)[(2Z)-2-[(2-chlorophenyl)imino]-4-methylidene-3-thia-1-azaspiro[4.5]dec-1-yl]methanone | |
| 0.0014 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-aminobenzene-1,3,5-trisulfonamide | |
| 0.0016 | - |
pH and temperature not specified in the publication | Homo sapiens | 7-chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one | |
| 0.0016 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(3-chlorophenyl)-5,6-dihydro-4H-cyclopenta[d][1,2]oxazole-3-carboxamide | |
| 0.0017 | - |
pH and temperature not specified in the publication | Homo sapiens | [4-(2,5-dimethyl-1H-pyrrol-1-yl)phenoxy]acetic acid | |
| 0.0017 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[(Z)-(4-hydroxy-3-methylphenyl)(3-methyl-4-methylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzoic acid | |
| 0.0017 | - |
pH and temperature not specified in the publication | Homo sapiens | 4'-(2-chloro-6-nitrophenoxy)biphenyl-4-yl 4-tert-butylbenzenesulfonate | |
| 0.0018 | - |
pH and temperature not specified in the publication | Homo sapiens | (3a'S,6a'R)-5'-(1,3-benzodioxol-5-ylmethyl)-3'-(2-carboxyethyl)-7-chloro-2,4',6'-trioxo-1,2,3',3a',4',5',6',6a'-octahydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrol[2]ium] | |
| 0.0018 | - |
pH and temperature not specified in the publication | Homo sapiens | biphenyl-4,4'-diyl bis(3,4-dichlorobenzenesulfonate) | |
| 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-(3-bromo-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-methylprop-2-enoic acid | |
| 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | (2R)-1-(1-benzofuran-2-yl)-2-(1,3-benzothiazol-2-yl)-2-hydroxyethanone | |
| 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | 1,4-dihydroxy-5,8-bis([2-[(2-hydroxyethyl)amino]ethyl]amino)anthracene-9,10-dione | |
| 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(2,4-dichlorophenyl)-6-nitro-4H-3,1-benzoxazin-4-one | |
| 0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[3-(1,3-benzothiazol-2-yl)-6-(propan-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide | |
| 0.0021 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine | |
| 0.0028 | - |
pH and temperature not specified in the publication | Homo sapiens | (5E)-1-(furan-2-ylmethyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.0029 | - |
pH and temperature not specified in the publication | Homo sapiens | 8-[(2E)-2-(1,3-benzodioxol-5-ylmethylidene)hydrazinyl]-6-methyl[1,3]dioxolo[4,5-g]quinoline | |
| 0.0029 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[3-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide | |
| 0.0029 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[3-(4-phenyl-1,3-thiazol-2-yl)-6-(propan-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide | |
| 0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-2-[(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-4-methoxybutanoic acid | |
| 0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-methylprop-2-enoic acid | |
| 0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-(2-chloro-4,5-dimethoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-2-methylprop-2-enoic acid | |
| 0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | 1,3-bis(1,3-benzothiazol-2-ylsulfanyl)propan-2-one | |
| 0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[(5R)-3-(naphthalen-2-yl)-5-phenyl-2,5-dihydro-1H-pyrazol-1-yl]-2-oxoethyl 5-nitrothiophene-2-carboxylate | |
| 0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[5-[1-(carboxymethyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-phenylpropanoic acid | |
| 0.0031 | - |
pH and temperature not specified in the publication | Homo sapiens | 7-nitro-1H-indole-2-carboxylic acid | |
| 0.0033 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[3-(1,3-benzothiazol-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl]acetamide | |
| 0.004 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,2'-[butane-1,4-diylbis(1H-benzimidazole-2,1-diyl)]diacetic acid | |
| 0.004 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(carboxymethyl)-4-([4-[(4-carboxyphenyl)sulfanyl]phenyl]sulfonyl)benzoic acid | |
| 0.004 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[1-(carboxymethyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]propanoic acid | |
| 0.004 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(9,10-dioxo-9,10-dihydroanthracen-1-yl)-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide | |
| 0.0041 | - |
pH and temperature not specified in the publication | Homo sapiens | 8-[(2E)-2-[(9-ethyl-9H-carbazol-3-yl)methylidene]hydrazinyl]-6-methyl[1,3]dioxolo[4,5-g]quinoline | |
| 0.0044 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-methyl-4-[(1E)-1-[2-(6-methyl[1,3]dioxolo[4,5-g]quinolin-8-yl)hydrazinylidene]ethyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one | |
| 0.005 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[[2-(ethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one | |
| 0.005 | - |
pH and temperature not specified in the publication | Homo sapiens | 5,5'-[ethane-1,2-diylbis(sulfanediylmethanediyl)]bis(2-methylfuran-3-carboxylic acid) | |
| 0.0068 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-benzyl-1-(3-[[(3-nitrophenyl)sulfonyl]amino]quinoxalin-2-yl)pyridinium | |
| 0.0068 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[(4Z)-4-([5-[4-chloro-3-(ethoxycarbonyl)phenyl]furan-2-yl]methylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid | |
| 0.0071 | - |
pH and temperature not specified in the publication | Homo sapiens | tetrahydrofuran-2-ylmethyl 6-(furan-2-yl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate | |
| 0.00776 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-amino-4-hydroxy-5-[(E)-(4-nitro-2-sulfophenyl)diazenyl]naphthalene-2-sulfonic acid | |
| 0.0085 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]-N-methoxydodecanamide | |
| 0.00885 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-amino-5-[(E)-(4-amino-2-sulfophenyl)diazenyl]-4-hydroxynaphthalene-2-sulfonic acid | |
| 0.01 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]dodecanoic acid | |
| 0.016 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[(3-chlorobenzyl)carbamoyl]-2-methoxybenzoic acid | |
| 0.018 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[(3,4-dichlorobenzyl)carbamoyl]-2-methoxybenzoic acid | |
| 0.018 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[(3,4-dimethoxybenzyl)carbamoyl]-2-methoxybenzoic acid | |
| 0.019 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-methoxy-3-[(3-methoxybenzyl)carbamoyl]benzoic acid | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | protein acetylation is an important protein modification in living cells and has an impact on pathological conditions. A profound deregulation of APE1/Ref-1 acetylation (on Lys35) status in triple negative breast cancer is revealed | Homo sapiens |
| physiological function | human apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional protein which is essential in the base excision repair (BER) pathway of DNA lesions caused by oxidation and alkylation. This protein hydrolyzes DNA adjacent to the 5'-end of an apurinic/apyrimidinic (AP) site to produce a nick with a 3'-hydroxyl group and a 5'-deoxyribose phosphate moiety or activates the DNA binding activity of certain transcription factors through its redox function. Role for APE1/Ref-1 in the pathogenesis of cancer and in resistance to DNA-interactive drugs. APE1/Ref-1 plays a vital role in mammalian cells with implication in human pathologies. DNA damage and chronic oxidative stress are involved in various neurodegenerative disorders, including Alzheimer's, Parkinson's, Huntington's diseases, and amyotrophic lateral sclerosis. APE1/Ref-1 signaling pathway in hepatocellular carcinoma stimulates cellular proliferation, enhances anti-apoptosis, and facilitates metastasis | Homo sapiens |
| physiological function | human enzyme APE2 performs most of the essential functional residues of the exonuclease III-like proteins. APE2 has 518 amino acids. Unlike APE1/Ref-1, APE2 shows only weak capacity to exhibit AP site repair activity. APE2 has no the N-terminal tail that is present in APE1/Ref-1 and as such does not possess redox activity | Homo sapiens |
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Release 2023.1 (January 2023)
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