Literature summary for 4.2.99.18 extracted from

Cho, K.J.; Kim, H.J.; Park, S.C.; Kim, H.W.; Kim, G.W.
Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death (2010), Mol. Cell. Neurosci., 45, 267-276.

Search for more literature for 4.2.99.18

Inhibitors

Inhibitors	Comment	Organism	Structure
Kainic acid	APE/Ref-1 is decreased by kainic acid injury in a time-dependent manner at the level of proteins, not transcripts	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

General Information

General Information	Comment	Organism
physiological function	overexpression of APE/Ref-1 using adenovirus and restoration of APE small peptides significantly reduces kainic acid-induced hippocampal cell death. Both silencing of APE/Ref-1 by siRNA and inhibition of endonuclease by an antibody significantly increase caspase-3 activity and apoptotic cell death triggered from the early time after exposure to kainic acid. Findings suggest that cell death is initiated by reducing APE/Ref-1 protein and inhibiting its repair function in spite of enough protein amounts	Mus musculus

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Release 2023.1 (January 2023)