Literature summary for 4.2.99.18 extracted from

Jedinak, A.; Dudhgaonkar, S.; Kelley, M.R.; Sliva, D.
Apurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages (2011), Anticancer Res., 31, 379-385.

Search for more literature for 4.2.99.18

Application

Application	Comment	Organism
medicine	pharmacological inhibition of APE1 by E3330 suppresses inflammatory response in activated macrophages	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
E3330	APE1 redox-specific inhibitor. E3330 suppresses secretion of inflammatory cytokines including tumor necrosis factor-alpha, interleukin IL-6 and IL-12 and inflammatory mediators nitric oxide as well as prostaglandin E2 from lipopolysaccharide-stimulated RAW264.7 cells and leads to down-regulation of the lipopolysaccharide-dependent expression of inducible nitric oxide synthase and cyclooxygenase-2 genes in the RAW264.7 cells. The effects of E3330 are mediated by the inhibition of transcription factors nuclear factor-kappaB and activator protein 1 in lipopolysaccharide-stimulated macrophages	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
RAW-264.7 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
APE1/Ref-1	-	Mus musculus
multi-functional apyrimidinic endonuclease1/redox factor-1	-	Mus musculus

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Release 2023.1 (January 2023)