Literature summary for 4.2.99.18 extracted from

Mitra, S.; Izumi, T.; Boldogh, I.; Bhakat, K.K.; Chattopadhyay, R.; Szczesny, B.
Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein (2007), DNA Repair, 6, 461-469.

Search for more literature for 4.2.99.18

Inhibitors

Inhibitors	Comment	Organism	Structure
granzyme A	granzyme A cleaves APE1 at Lys31 and inactivates it	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Mus musculus	5829	-
mitochondrion	mtAPE, N-terminal truncation product of APE1	Mus musculus	5739	-
nucleus	-	Mus musculus	5634	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Mus musculus	-
liver	-	Mus musculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.0000015	-	age-dependent modulation of APE activity in mouse liver organelles, 4-months, mitochondria	Mus musculus
0.0000096	-	age-dependent modulation of APE activity in mouse liver organelles, 10-months, mitochondria	Mus musculus
0.0000096	-	age-dependent modulation of APE activity in mouse liver organelles, 20-months, mitochondria	Mus musculus
0.0000196	-	age-dependent modulation of APE activity in mouse liver organelles, 10-months, total extract	Mus musculus
0.0000232	-	age-dependent modulation of APE activity in mouse liver organelles, 20-months, total extract	Mus musculus
0.0000236	-	age-dependent modulation of APE activity in mouse liver organelles, 4-months, total extract	Mus musculus
0.000038	-	age-dependent modulation of APE activity in mouse liver organelles, 4-months, nuclear	Mus musculus
0.0000485	-	age-dependent modulation of APE activity in mouse liver organelles, 10-months, nuclear	Mus musculus
0.000072	-	age-dependent modulation of APE activity in mouse liver organelles, 20-months, nuclear	Mus musculus

Synonyms

Synonyms	Comment	Organism
AP-endonuclease 1	-	Mus musculus
APE1	-	Mus musculus
apurinic/apyrimidinic endonuclease 1	-	Mus musculus

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Release 2023.1 (January 2023)