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Literature summary for 4.2.99.18 extracted from

  • Jackson, E.B.; Theriot, C.A.; Chattopadhyay, R.; Mitra, S.; Izumi, T.
    Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1) (2005), Nucleic Acids Res., 33, 3303-3312.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
DELTA1-20 nuclear localization is significantly decreased Homo sapiens
DELTA1-7 mutant shows nearly normal nuclear localization Homo sapiens
DELTA1-7/E12A/D13A nuclear localization is significantly decreased Homo sapiens
E12A/D13A mutant shows nearly normal nuclear localization Homo sapiens
K3l/R4L/K6L/K7L as the wild-type enzyme the mutant enzyme is predominantly localitzed in the nucleus Homo sapiens
K6R/K7R no significant difference in nuclear localization between wild-type enzyme and mutant enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus the first 7 residues and residues 8-13 can independently promote nuclear import Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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 expressed in fibroblasts of Mus musculus
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