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Literature summary for 4.2.99.18 extracted from

  • Wang, D.; Luo, M.; Kelley, M.R.
    Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition (2004), Mol. Cancer Ther., 3, 679-686.
    View publication on PubMed

Application

Application Comment Organism
medicine a decrease in APE1 levels in silencing RNA-treated osteogenic sarcoma cells leads to enhanced cell sensitization to the DNA damaging agents: methyl methanesulfonate, H2O2, ionizing radiation and chemotherapeutic agents Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
osteosarcoma cell APE1 protein is elevated in 72% of the tissues and among those with a known clinical outcome. There is a significant correlation between high APE1 expression levels and reduced survival times Homo sapiens
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Synonyms

Synonyms Comment Organism
APE1
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Homo sapiens
apurinic endonuclease 1
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Homo sapiens