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Literature summary for 4.2.99.18 extracted from

  • Doetsch, P.W.; Helland, D.E.; Haseltine, W.A.
    Mechanism of action of a mammalian DNA repair endonuclease (1986), Biochemistry, 25, 2212-2220.
    View publication on PubMed
Search for more literature for 4.2.99.18

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Bos taurus
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 fragments of DNA
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 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate mechanism Bos taurus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
 Bos taurus fragments of DNA
-
 ?
DNA removes UV light and osmium tetroxide damaged bases via an N-glycosylase activity followed by a 3'-purinic/apyrimidinic endonuclease activity, product is a nucleoside-free site flanked by 3'- and 5'-terminal phosphate groups Bos taurus fragments of DNA
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 ?
additional information enzyme also has DNA N-glycosylase activity Bos taurus ?
-
 ?